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Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration.
Mdachi RE, Thuita JK, Kagira JM, Ngotho JM, Murilla GA, Ndung'u JM, Tidwell RR, Hall JE, Brun R. Mdachi RE, et al. Antimicrob Agents Chemother. 2009 Mar;53(3):953-7. doi: 10.1128/AAC.00831-08. Epub 2008 Dec 8. Antimicrob Agents Chemother. 2009. PMID: 19064893 Free PMC article.
Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis.
Thuita JK, Wolf KK, Murilla GA, Liu Q, Mutuku JN, Chen Y, Bridges AS, Mdachi RE, Ismail MA, Ching S, Boykin DW, Hall JE, Tidwell RR, Paine MF, Brun R, Wang MZ. Thuita JK, et al. Among authors: mdachi re. PLoS Negl Trop Dis. 2013 Jun 6;7(6):e2230. doi: 10.1371/journal.pntd.0002230. Print 2013. PLoS Negl Trop Dis. 2013. PMID: 23755309 Free PMC article.
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