Huo C - Search Results

1

Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.

Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, Nixon RA. Pensalfini A, et al. Among authors: huo c. Cell Rep. 2020 Nov 24;33(8):108420. doi: 10.1016/j.celrep.2020.108420. Cell Rep. 2020. PMID: 33238112 Free PMC article.

2

Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques.

Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA. Lee JH, et al. Among authors: huo c. Nat Neurosci. 2022 Jun;25(6):688-701. doi: 10.1038/s41593-022-01084-8. Epub 2022 Jun 2. Nat Neurosci. 2022. PMID: 35654956 Free PMC article.

3

Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits.

Yang DS, Stavrides P, Saito M, Kumar A, Rodriguez-Navarro JA, Pawlik M, Huo C, Walkley SU, Saito M, Cuervo AM, Nixon RA. Yang DS, et al. Among authors: huo c. Brain. 2014 Dec;137(Pt 12):3300-18. doi: 10.1093/brain/awu278. Epub 2014 Sep 29. Brain. 2014. PMID: 25270989 Free PMC article.

4

Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice.

Yang DS, Stavrides P, Kumar A, Jiang Y, Mohan PS, Ohno M, Dobrenis K, Davidson CD, Saito M, Pawlik M, Huo C, Walkley SU, Nixon RA. Yang DS, et al. Among authors: huo c. Hum Mol Genet. 2017 Mar 1;26(5):843-859. doi: 10.1093/hmg/ddx001. Hum Mol Genet. 2017. PMID: 28062666 Free PMC article.

5

Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo.

Lee JH, Rao MV, Yang DS, Stavrides P, Im E, Pensalfini A, Huo C, Sarkar P, Yoshimori T, Nixon RA. Lee JH, et al. Among authors: huo c. Autophagy. 2019 Mar;15(3):543-557. doi: 10.1080/15548627.2018.1528812. Epub 2018 Oct 26. Autophagy. 2019. PMID: 30269645 Free PMC article.

6

Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca²⁺ efflux and disrupted by PSEN1 loss of function.

Lie PPY, Yoo L, Goulbourne CN, Berg MJ, Stavrides P, Huo C, Lee JH, Nixon RA. Lie PPY, et al. Among authors: huo c. Sci Adv. 2022 Apr 29;8(17):eabj5716. doi: 10.1126/sciadv.abj5716. Epub 2022 Apr 29. Sci Adv. 2022. PMID: 35486730 Free PMC article.

7

Nortriptyline delays disease onset in models of chronic neurodegeneration.

Wang H, Guan Y, Wang X, Smith K, Cormier K, Zhu S, Stavrovskaya IG, Huo C, Ferrante RJ, Kristal BS, Friedlander RM. Wang H, et al. Among authors: huo c. Eur J Neurosci. 2007 Aug;26(3):633-41. doi: 10.1111/j.1460-9568.2007.05663.x. Eur J Neurosci. 2007. PMID: 17686041

8

Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease.

Wang X, Wang H, Figueroa BE, Zhang WH, Huo C, Guan Y, Zhang Y, Bruey JM, Reed JC, Friedlander RM. Wang X, et al. Among authors: huo c. J Neurosci. 2005 Dec 14;25(50):11645-54. doi: 10.1523/JNEUROSCI.4181-05.2005. J Neurosci. 2005. PMID: 16354923 Free PMC article.

9

Increased stem cell proliferation in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice.

Guan YJ, Wang X, Wang HY, Kawagishi K, Ryu H, Huo CF, Shimony EM, Kristal BS, Kuhn HG, Friedlander RM. Guan YJ, et al. J Neurochem. 2007 Aug;102(4):1125-38. doi: 10.1111/j.1471-4159.2007.04610.x. Epub 2007 Apr 30. J Neurochem. 2007. PMID: 17472707 Free article.

10

Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death.

Zhang WH, Wang X, Narayanan M, Zhang Y, Huo C, Reed JC, Friedlander RM. Zhang WH, et al. Among authors: huo c. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16012-7. doi: 10.1073/pnas.2534856100. Epub 2003 Dec 8. Proc Natl Acad Sci U S A. 2003. PMID: 14663141 Free PMC article.

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