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Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, Nixon RA. Pensalfini A, et al. Among authors: jiang y. Cell Rep. 2020 Nov 24;33(8):108420. doi: 10.1016/j.celrep.2020.108420. Cell Rep. 2020. PMID: 33238112 Free PMC article.
Assessing Rab5 Activation in Health and Disease.
Pensalfini A, Jiang Y, Kim S, Nixon RA. Pensalfini A, et al. Among authors: jiang y. Methods Mol Biol. 2021;2293:273-294. doi: 10.1007/978-1-0716-1346-7_20. Methods Mol Biol. 2021. PMID: 34453725 Free PMC article.
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production.
Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. Grbovic OM, et al. Among authors: jiang y. J Biol Chem. 2003 Aug 15;278(33):31261-8. doi: 10.1074/jbc.M304122200. Epub 2003 May 20. J Biol Chem. 2003. PMID: 12761223 Free article.
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Näslund J, Mathews PM, Cataldo AM, Nixon RA. Yu WH, et al. Among authors: jiang y. J Cell Biol. 2005 Oct 10;171(1):87-98. doi: 10.1083/jcb.200505082. Epub 2005 Oct 3. J Cell Biol. 2005. PMID: 16203860 Free PMC article.
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.
Rao MV, Mohan PS, Peterhoff CM, Yang DS, Schmidt SD, Stavrides PH, Campbell J, Chen Y, Jiang Y, Paskevich PA, Cataldo AM, Haroutunian V, Nixon RA. Rao MV, et al. Among authors: jiang y. J Neurosci. 2008 Nov 19;28(47):12241-54. doi: 10.1523/JNEUROSCI.4119-08.2008. J Neurosci. 2008. PMID: 19020018 Free PMC article.
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. Yang DS, et al. Among authors: jiang y. Brain. 2011 Jan;134(Pt 1):258-77. doi: 10.1093/brain/awq341. Brain. 2011. PMID: 21186265 Free PMC article.
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