Das K - Search Results

1

Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues.

Gu W, Martinez S, Nguyen H, Xu H, Herdewijn P, De Jonghe S, Das K. Gu W, et al. Among authors: das k. J Med Chem. 2021 Jan 14;64(1):782-796. doi: 10.1021/acs.jmedchem.0c01747. Epub 2020 Dec 23. J Med Chem. 2021. PMID: 33356231

2

Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.

Heeres J, de Jonge MR, Koymans LM, Daeyaert FF, Vinkers M, Van Aken KJ, Arnold E, Das K, Kilonda A, Hoornaert GJ, Compernolle F, Cegla M, Azzam RA, Andries K, de Béthune MP, Azijn H, Pauwels R, Lewi PJ, Janssen PA. Heeres J, et al. Among authors: das k. J Med Chem. 2005 Mar 24;48(6):1910-8. doi: 10.1021/jm040829e. J Med Chem. 2005. PMID: 15771435

3

Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase.

Cullen MD, Ho WC, Bauman JD, Das K, Arnold E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Cullen MD, et al. Among authors: das k. J Med Chem. 2009 Oct 22;52(20):6467-73. doi: 10.1021/jm901167t. J Med Chem. 2009. PMID: 19775161 Free PMC article.

4

Conformational landscape of the human immunodeficiency virus type 1 reverse transcriptase non-nucleoside inhibitor binding pocket: lessons for inhibitor design from a cluster analysis of many crystal structures.

Paris KA, Haq O, Felts AK, Das K, Arnold E, Levy RM. Paris KA, et al. Among authors: das k. J Med Chem. 2009 Oct 22;52(20):6413-20. doi: 10.1021/jm900854h. J Med Chem. 2009. PMID: 19827836 Free PMC article.

5

HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.

Das K, Martinez SE, Bauman JD, Arnold E. Das K, et al. Nat Struct Mol Biol. 2012 Jan 22;19(2):253-9. doi: 10.1038/nsmb.2223. Nat Struct Mol Biol. 2012. PMID: 22266819 Free PMC article.

6

Phenyl substituted 3-hydroxypyridin-2(1H)-ones: inhibitors of influenza A endonuclease.

Parhi AK, Xiang A, Bauman JD, Patel D, Vijayan RS, Das K, Arnold E, Lavoie EJ. Parhi AK, et al. Among authors: das k. Bioorg Med Chem. 2013 Nov 1;21(21):6435-46. doi: 10.1016/j.bmc.2013.08.053. Epub 2013 Sep 4. Bioorg Med Chem. 2013. PMID: 24055080

7

Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.

Das K, Martinez SE, Bandwar RP, Arnold E. Das K, et al. Nucleic Acids Res. 2014 Jul;42(12):8125-37. doi: 10.1093/nar/gku487. Epub 2014 May 31. Nucleic Acids Res. 2014. PMID: 24880687 Free PMC article.

8

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.

Balzarini J, Das K, Bernatchez JA, Martinez SE, Ngure M, Keane S, Ford A, Maguire N, Mullins N, John J, Kim Y, Dehaen W, Vande Voorde J, Liekens S, Naesens L, Götte M, Maguire AR, Arnold E. Balzarini J, et al. Among authors: das k. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3475-80. doi: 10.1073/pnas.1420233112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733891 Free PMC article.

9

Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.

Das K, Balzarini J, Miller MT, Maguire AR, DeStefano JJ, Arnold E. Das K, et al. ACS Chem Biol. 2016 Aug 19;11(8):2158-64. doi: 10.1021/acschembio.6b00187. Epub 2016 Jun 6. ACS Chem Biol. 2016. PMID: 27192549 Free PMC article.

10

Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.

Das K, Martinez SE, Arnold E. Das K, et al. Antimicrob Agents Chemother. 2017 May 24;61(6):e00224-17. doi: 10.1128/AAC.00224-17. Print 2017 Jun. Antimicrob Agents Chemother. 2017. PMID: 28396546 Free PMC article.

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