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On the utility of CSF1R inhibitors.
Green KN, Hume DA. Green KN, et al. Among authors: hume da. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2019695118. doi: 10.1073/pnas.2019695118. Proc Natl Acad Sci U S A. 2021. PMID: 33446486 Free PMC article. No abstract available.
Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus.
Pridans C, Raper A, Davis GM, Alves J, Sauter KA, Lefevre L, Regan T, Meek S, Sutherland L, Thomson AJ, Clohisey S, Bush SJ, Rojo R, Lisowski ZM, Wallace R, Grabert K, Upton KR, Tsai YT, Brown D, Smith LB, Summers KM, Mabbott NA, Piccardo P, Cheeseman MT, Burdon T, Hume DA. Pridans C, et al. Among authors: hume da. J Immunol. 2018 Nov 1;201(9):2683-2699. doi: 10.4049/jimmunol.1701783. Epub 2018 Sep 24. J Immunol. 2018. PMID: 30249809 Free PMC article.
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C. Rojo R, et al. Among authors: hume da. Nat Commun. 2019 Jul 19;10(1):3215. doi: 10.1038/s41467-019-11053-8. Nat Commun. 2019. PMID: 31324781 Free PMC article.
A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System.
Grabert K, Sehgal A, Irvine KM, Wollscheid-Lengeling E, Ozdemir DD, Stables J, Luke GA, Ryan MD, Adamson A, Humphreys NE, Sandrock CJ, Rojo R, Verkasalo VA, Mueller W, Hohenstein P, Pettit AR, Pridans C, Hume DA. Grabert K, et al. Among authors: hume da. J Immunol. 2020 Dec 1;205(11):3154-3166. doi: 10.4049/jimmunol.2000835. Epub 2020 Nov 2. J Immunol. 2020. PMID: 33139489
Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations.
Patkar OL, Caruso M, Teakle N, Keshvari S, Bush SJ, Pridans C, Belmer A, Summers KM, Irvine KM, Hume DA. Patkar OL, et al. Among authors: hume da. Neurobiol Dis. 2021 Apr;151:105268. doi: 10.1016/j.nbd.2021.105268. Epub 2021 Jan 12. Neurobiol Dis. 2021. PMID: 33450391 Free PMC article.
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation.
Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA. Keshvari S, et al. Among authors: hume da. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. eCollection 2021 Jun. PLoS Genet. 2021. PMID: 34081701 Free PMC article.
A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling.
Stables J, Green EK, Sehgal A, Patkar OL, Keshvari S, Taylor I, Ashcroft ME, Grabert K, Wollscheid-Lengeling E, Szymkowiak S, McColl BW, Adamson A, Humphreys NE, Mueller W, Starobova H, Vetter I, Shabestari SK, Blurton-Jones MM, Summers KM, Irvine KM, Pridans C, Hume DA. Stables J, et al. Among authors: hume da. Development. 2022 Apr 15;149(8):dev200237. doi: 10.1242/dev.200237. Epub 2022 Mar 25. Development. 2022. PMID: 35333324 Free PMC article.
457 results