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DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens.
Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2016857118. doi: 10.1073/pnas.2016857118.
Proc Natl Acad Sci U S A. 2021.
PMID: 33468643
Free PMC article.
Strategies for the Site-Specific Decoration of DNA Origami Nanostructures with Functionally Intact Proteins.
Hellmeier J, Platzer R, Mühlgrabner V, Schneider MC, Kurz E, Schütz GJ, Huppa JB, Sevcsik E.
Hellmeier J, et al.
ACS Nano. 2021 Sep 28;15(9):15057-15068. doi: 10.1021/acsnano.1c05411. Epub 2021 Aug 31.
ACS Nano. 2021.
PMID: 34463486
Free PMC article.
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Simultaneous multicolor fluorescence imaging using PSF splitting.
Van den Eynde R, Hertel F, Abakumov S, Krajnik B, Hugelier S, Auer A, Hellmeier J, Schlichthaerle T, Grattan RM, Lidke DS, Jungmann R, Leutenegger M, Vandenberg W, Dedecker P.
Van den Eynde R, et al. Among authors: hellmeier j.
Nat Methods. 2024 Sep 6. doi: 10.1038/s41592-024-02383-7. Online ahead of print.
Nat Methods. 2024.
PMID: 39242832
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CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer.
Menon AP, Villanueva H, Meraviglia-Crivelli D, van Santen HM, Hellmeier J, Zheleva A, Nonateli F, Peters T, Wachsmann TLA, Hernandez-Rueda M, Huppa JB, Schütz GJ, Sevcsik E, Moreno B, Pastor F.
Menon AP, et al. Among authors: hellmeier j.
Mol Ther Nucleic Acids. 2024 Apr 23;35(2):102198. doi: 10.1016/j.omtn.2024.102198. eCollection 2024 Jun 11.
Mol Ther Nucleic Acids. 2024.
PMID: 38745854
Free PMC article.
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Quantification of absolute labeling efficiency at the single-protein level.
Hellmeier J, Strauss S, Xu S, Masullo LA, Unterauer EM, Kowalewski R, Jungmann R.
Hellmeier J, et al.
Nat Methods. 2024 Sep;21(9):1702-1707. doi: 10.1038/s41592-024-02242-5. Epub 2024 Apr 24.
Nat Methods. 2024.
PMID: 38658647
Free PMC article.
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Balancing the Nanoscale Organization in Multivalent Materials for Functional Inhibition of the Programmed Death-1 Immune Checkpoint.
Paloja K, Weiden J, Hellmeier J, Eklund AS, Reinhardt SCM, Parish IA, Jungmann R, Bastings MMC.
Paloja K, et al. Among authors: hellmeier j.
ACS Nano. 2024 Jan 16;18(2):1381-1395. doi: 10.1021/acsnano.3c06552. Epub 2023 Dec 21.
ACS Nano. 2024.
PMID: 38126310
Free PMC article.
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Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion.
Platzer R, Hellmeier J, Göhring J, Perez ID, Schatzlmaier P, Bodner C, Focke-Tejkl M, Schütz GJ, Sevcsik E, Stockinger H, Brameshuber M, Huppa JB.
Platzer R, et al. Among authors: hellmeier j.
EMBO Rep. 2023 Nov 6;24(11):e57842. doi: 10.15252/embr.202357842. Epub 2023 Sep 28.
EMBO Rep. 2023.
PMID: 37768718
Free PMC article.
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A DNA Origami-Based Biointerface to Interrogate the Spatial Requirements for Sensitized T-Cell Antigen Recognition.
Hellmeier J, Platzer R, Huppa JB, Sevcsik E.
Hellmeier J, et al.
Methods Mol Biol. 2023;2654:277-302. doi: 10.1007/978-1-0716-3135-5_18.
Methods Mol Biol. 2023.
PMID: 37106189
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