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Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, Guillén MJ, Losada A, Avilés P, Schotsaert M, Zwaka T, Vignuzzi M, Shokat KM, Krogan NJ, García-Sastre A. White KM, et al. Among authors: guillen mj. Science. 2021 Feb 26;371(6532):926-931. doi: 10.1126/science.abf4058. Epub 2021 Jan 25. Science. 2021. PMID: 33495306 Free PMC article.
A new potential nano-oncological therapy based on polyamino acid nanocapsules.
Gonzalo T, Lollo G, Garcia-Fuentes M, Torres D, Correa J, Riguera R, Fernandez-Megia E, Calvo P, Avilés P, Guillén MJ, Alonso MJ. Gonzalo T, et al. Among authors: guillen mj. J Control Release. 2013 Jul 10;169(1-2):10-6. doi: 10.1016/j.jconrel.2013.03.037. J Control Release. 2013. PMID: 23591661
MI130004, a Novel Antibody-Drug Conjugate Combining Trastuzumab with a Molecule of Marine Origin, Shows Outstanding In Vivo Activity against HER2-Expressing Tumors.
Avilés P, Domínguez JM, Guillén MJ, Muñoz-Alonso MJ, Mateo C, Rodriguez-Acebes R, Molina-Guijarro JM, Francesch A, Martínez-Leal JF, Munt S, Galmarini CM, Cuevas C. Avilés P, et al. Among authors: guillen mj. Mol Cancer Ther. 2018 Apr;17(4):786-794. doi: 10.1158/1535-7163.MCT-17-0795. Epub 2018 Feb 13. Mol Cancer Ther. 2018. PMID: 29440297
Correlation between in vitro and in vivo activities of GM 237354, a new sordarin derivative, against Candida albicans in an in vitro pharmacokinetic-pharmacodynamic model and influence of protein binding.
Aviles P, Falcoz C, Guillén MJ, San Roman R, Gómez De Las Heras F, Gargallo-Viola D. Aviles P, et al. Among authors: guillen mj. Antimicrob Agents Chemother. 2001 Oct;45(10):2746-54. doi: 10.1128/AAC.45.10.2746-2754.2001. Antimicrob Agents Chemother. 2001. PMID: 11557464 Free PMC article.
23 results