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Page 1
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, Guillén MJ, Losada A, Avilés P, Schotsaert M, Zwaka T, Vignuzzi M, Shokat KM, Krogan NJ, García-Sastre A. White KM, et al. Among authors: krogan nj. Science. 2021 Feb 26;371(6532):926-931. doi: 10.1126/science.abf4058. Epub 2021 Jan 25. Science. 2021. PMID: 33495306 Free PMC article.
Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park HO, Hayles J, Hoe KL, Kim DU, Ideker T, Grewal SI, Weissman JS, Krogan NJ. Roguev A, et al. Among authors: krogan nj. Science. 2008 Oct 17;322(5900):405-10. doi: 10.1126/science.1162609. Epub 2008 Sep 25. Science. 2008. PMID: 18818364 Free PMC article.
Rewiring of genetic networks in response to DNA damage.
Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guénolé A, van Attikum H, Shokat KM, Kolodner RD, Huh WK, Aebersold R, Keogh MC, Krogan NJ, Ideker T. Bandyopadhyay S, et al. Among authors: krogan nj. Science. 2010 Dec 3;330(6009):1385-9. doi: 10.1126/science.1195618. Science. 2010. PMID: 21127252 Free PMC article.
Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.
Kliegman JI, Fiedler D, Ryan CJ, Xu YF, Su XY, Thomas D, Caccese MC, Cheng A, Shales M, Rabinowitz JD, Krogan NJ, Shokat KM. Kliegman JI, et al. Among authors: krogan nj. Cell Rep. 2013 Dec 26;5(6):1725-36. doi: 10.1016/j.celrep.2013.11.040. Epub 2013 Dec 19. Cell Rep. 2013. PMID: 24360963 Free PMC article.
Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.
Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakhshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S. Martins MM, et al. Among authors: krogan nj. Cancer Discov. 2015 Feb;5(2):154-67. doi: 10.1158/2159-8290.CD-14-0552. Epub 2014 Dec 12. Cancer Discov. 2015. PMID: 25501949 Free PMC article.
Differential genetic interactions of yeast stress response MAPK pathways.
Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ. Martin H, et al. Among authors: krogan nj. Mol Syst Biol. 2015 Apr 17;11(4):800. doi: 10.15252/msb.20145606. Mol Syst Biol. 2015. PMID: 25888283 Free PMC article.
Discovery and functional characterization of a neomorphic PTEN mutation.
Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee MC, De La Vega FM, Ford JM, Krogan NJ, Shokat KM, Oliver D, Halaszovich CR, Bustamante CD. Costa HA, et al. Among authors: krogan nj. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13976-81. doi: 10.1073/pnas.1422504112. Epub 2015 Oct 26. Proc Natl Acad Sci U S A. 2015. PMID: 26504226 Free PMC article.
Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.
Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I. Heaton NS, et al. Among authors: krogan nj. Immunity. 2016 Jan 19;44(1):46-58. doi: 10.1016/j.immuni.2015.12.017. Immunity. 2016. PMID: 26789921 Free PMC article.
Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.
Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VR, Inoue A, de Castro E, Moulton H, Stein DA, Sánchez-Aparicio MT, De Jesus PD, Nguyen Q, König R, Krogan NJ, García-Sastre A, Yoh SM, Chanda SK. Soonthornvacharin S, et al. Among authors: krogan nj. Nat Microbiol. 2017 Mar 1;2:17022. doi: 10.1038/nmicrobiol.2017.22. Nat Microbiol. 2017. PMID: 28248290 Free PMC article.
411 results