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Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration.
Bioorg Med Chem Lett. 2021 Mar 15;36:127821. doi: 10.1016/j.bmcl.2021.127821. Epub 2021 Jan 27.
Bioorg Med Chem Lett. 2021.
PMID: 33513387
Free PMC article.
Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers.
Fiolek TJ, Keel KL, Tepe JJ.
Fiolek TJ, et al.
ACS Chem Neurosci. 2021 Apr 21;12(8):1438-1448. doi: 10.1021/acschemneuro.1c00099. Epub 2021 Mar 31.
ACS Chem Neurosci. 2021.
PMID: 33788542
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Chemoenzymatic Synthesis of Trehalosamine, an Aminoglycoside Antibiotic and Precursor to Mycobacterial Imaging Probes.
Groenevelt JM, Meints LM, Stothard AI, Poston AW, Fiolek TJ, Finocchietti DH, Mulholand VM, Woodruff PJ, Swarts BM.
Groenevelt JM, et al. Among authors: fiolek tj.
J Org Chem. 2018 Aug 3;83(15):8662-8667. doi: 10.1021/acs.joc.8b00810. Epub 2018 Jul 23.
J Org Chem. 2018.
PMID: 29973045
Free PMC article.
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Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria.
García-Heredia A, Pohane AA, Melzer ES, Carr CR, Fiolek TJ, Rundell SR, Lim HC, Wagner JC, Morita YS, Swarts BM, Siegrist MS.
García-Heredia A, et al. Among authors: fiolek tj.
Elife. 2018 Sep 10;7:e37243. doi: 10.7554/eLife.37243.
Elife. 2018.
PMID: 30198841
Free PMC article.
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Engineering the Mycomembrane of Live Mycobacteria with an Expanded Set of Trehalose Monomycolate Analogues.
Fiolek TJ, Banahene N, Kavunja HW, Holmes NJ, Rylski AK, Pohane AA, Siegrist MS, Swarts BM.
Fiolek TJ, et al.
Chembiochem. 2019 May 15;20(10):1282-1291. doi: 10.1002/cbic.201800687. Epub 2019 Mar 18.
Chembiochem. 2019.
PMID: 30589191
Free PMC article.
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A chemical reporter strategy for detecting and identifying O-mycoloylated proteins in Corynebacterium.
Kavunja HW, Piligian BF, Fiolek TJ, Foley HN, Nathan TO, Swarts BM.
Kavunja HW, et al. Among authors: fiolek tj.
Chem Commun (Camb). 2016 Nov 22;52(95):13795-13798. doi: 10.1039/c6cc07143k.
Chem Commun (Camb). 2016.
PMID: 27831572
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