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Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration.
Bioorg Med Chem Lett. 2021 Mar 15;36:127821. doi: 10.1016/j.bmcl.2021.127821. Epub 2021 Jan 27.
Bioorg Med Chem Lett. 2021.
PMID: 33513387
Free PMC article.
Triflic anhydride mediated synthesis of 3,4-dihydroquinazolines: a three-component one-pot tandem procedure.
Magyar CL, Wall TJ, Davies SB, Campbell MV, Barna HA, Smith SR, Savich CJ, Mosey RA.
Magyar CL, et al. Among authors: savich cj.
Org Biomol Chem. 2019 Aug 28;17(34):7995-8000. doi: 10.1039/c9ob01596e.
Org Biomol Chem. 2019.
PMID: 31408069
Free PMC article.
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