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SLC6A14 deficiency is linked to obesity, fatty liver, and metabolic syndrome but only under conditions of a high-fat diet.
Sivaprakasam S, Sikder MOF, Ramalingam L, Kaur G, Dufour JM, Moustaid-Moussa N, Wachtel MS, Ganapathy V. Sivaprakasam S, et al. Among authors: ganapathy v. Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166087. doi: 10.1016/j.bbadis.2021.166087. Epub 2021 Jan 26. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 33513428 Free article.
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V. Singh N, et al. Among authors: ganapathy v. Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9. Immunity. 2014. PMID: 24412617 Free PMC article.
An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis.
Sivaprakasam S, Gurav A, Paschall AV, Coe GL, Chaudhary K, Cai Y, Kolhe R, Martin P, Browning D, Huang L, Shi H, Sifuentes H, Vijay-Kumar M, Thompson SA, Munn DH, Mellor A, McGaha TL, Shiao P, Cutler CW, Liu K, Ganapathy V, Li H, Singh N. Sivaprakasam S, et al. Among authors: ganapathy v. Oncogenesis. 2016 Jun 27;5(6):e238. doi: 10.1038/oncsis.2016.38. Oncogenesis. 2016. PMID: 27348268 Free PMC article.
623 results