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Genomic characterization of relapsed acute myeloid leukemia reveals novel putative therapeutic targets.
Stratmann S, Yones SA, Mayrhofer M, Norgren N, Skaftason A, Sun J, Smolinska K, Komorowski J, Herlin MK, Sundström C, Eriksson A, Höglund M, Palle J, Abrahamsson J, Jahnukainen K, Munthe-Kaas MC, Zeller B, Tamm KP, Cavelier L, Holmfeldt L. Stratmann S, et al. Among authors: hoglund m. Blood Adv. 2021 Feb 9;5(3):900-912. doi: 10.1182/bloodadvances.2020003709. Blood Adv. 2021. PMID: 33560403 Free PMC article.
Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia.
Eriksson A, Höglund M, Lindhagen E, Aleskog A, Hassan SB, Ekholm C, Fhölenhag K, Jensen AJ, Löthgren A, Scobie M, Larsson R, Parrow V. Eriksson A, et al. Among authors: hoglund m. Biochem Pharmacol. 2010 Nov 15;80(10):1507-16. doi: 10.1016/j.bcp.2010.08.002. Epub 2010 Aug 10. Biochem Pharmacol. 2010. PMID: 20705060
Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks.
Deneberg S, Guardiola P, Lennartsson A, Qu Y, Gaidzik V, Blanchet O, Karimi M, Bengtzén S, Nahi H, Uggla B, Tidefelt U, Höglund M, Paul C, Ekwall K, Döhner K, Lehmann S. Deneberg S, et al. Among authors: hoglund m. Blood. 2011 Nov 17;118(20):5573-82. doi: 10.1182/blood-2011-01-332353. Epub 2011 Sep 29. Blood. 2011. PMID: 21960591 Free article.
AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia.
Eriksson A, Kalushkova A, Jarvius M, Hilhorst R, Rickardson L, Kultima HG, de Wijn R, Hovestad L, Fryknäs M, Öberg F, Larsson R, Parrow V, Höglund M. Eriksson A, et al. Among authors: hoglund m. Biochem Pharmacol. 2014 Jan 15;87(2):284-91. doi: 10.1016/j.bcp.2013.10.022. Epub 2013 Nov 4. Biochem Pharmacol. 2014. PMID: 24200998 Free article. Clinical Trial.
370 results