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Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation.
Roberts A, Bentley L, Tang T, Stewart F, Pallini C, Juvvanapudi J, Wallace GR, Cooper AJ, Scott A, Thickett D, Lugg ST, Bancroft H, Hemming B, Ferris C, Langman G, Robinson A, Chapman J, Naidu B, Pinkney T, Taylor GS, Brock K, Stamataki Z, Brady CA, Curnow SJ, Gordon J, Qureshi O, Barnes NM. Roberts A, et al. Among authors: brady ca. Sci Rep. 2021 Feb 17;11(1):4030. doi: 10.1038/s41598-021-83612-3. Sci Rep. 2021. PMID: 33597595 Free PMC article.
Inosine Acedoben Dimepranol promotes an early and sustained increase in the natural killer cell component of circulating lymphocytes: A clinical trial supporting anti-viral indications.
Rumel Ahmed S, Newman AS, O'Daly J, Duffy S, Grafton G, Brady CA, John Curnow S, Barnes NM, Gordon J. Rumel Ahmed S, et al. Among authors: brady ca. Int Immunopharmacol. 2017 Jan;42:108-114. doi: 10.1016/j.intimp.2016.11.023. Epub 2016 Nov 29. Int Immunopharmacol. 2017. PMID: 27912146 Free article. Clinical Trial.
CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome.
Roberts A, Grafton G, Powell AD, Brock K, Chen C, Xie D, Huang J, Liu S, Cooper AJ, Brady CA, Qureshi O, Stamataki Z, Manning DD, Moore NA, Sargent BJ, Guzzo PR, Barnes NM. Roberts A, et al. Among authors: brady ca. J Pharmacol Exp Ther. 2020 Apr;373(1):122-134. doi: 10.1124/jpet.119.261008. Epub 2020 Feb 26. J Pharmacol Exp Ther. 2020. PMID: 32102919
5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor.
Newman AS, Batis N, Grafton G, Caputo F, Brady CA, Lambert JJ, Peters JA, Gordon J, Brain KL, Powell AD, Barnes NM. Newman AS, et al. Among authors: brady ca. Br J Pharmacol. 2013 Jul;169(6):1228-38. doi: 10.1111/bph.12213. Br J Pharmacol. 2013. PMID: 23594147 Free PMC article.
The discovery of diazepinone-based 5-HT3 receptor partial agonists.
Manning DD, Guo C, Zhang Z, Ryan KN, Naginskaya J, Choo SH, Masih L, Earley WG, Wierschke JD, Newman AS, Brady CA, Barnes NM, Guzzo PR. Manning DD, et al. Among authors: brady ca. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2578-81. doi: 10.1016/j.bmcl.2014.03.074. Epub 2014 Apr 2. Bioorg Med Chem Lett. 2014. PMID: 24755431
41 results