Olsen CA - Search Results

1

High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays.

Moreno-Yruela C, Olsen CA. Moreno-Yruela C, et al. Among authors: olsen ca. STAR Protoc. 2021 Feb 3;2(1):100313. doi: 10.1016/j.xpro.2021.100313. eCollection 2021 Mar 19. STAR Protoc. 2021. PMID: 33659897 Free PMC article.

2

The effect of various zinc binding groups on inhibition of histone deacetylases 1-11.

Madsen AS, Kristensen HM, Lanz G, Olsen CA. Madsen AS, et al. Among authors: olsen ca. ChemMedChem. 2014 Mar;9(3):614-26. doi: 10.1002/cmdc.201300433. Epub 2013 Dec 27. ChemMedChem. 2014. PMID: 24375963

3

A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation.

Galleano I, Schiedel M, Jung M, Madsen AS, Olsen CA. Galleano I, et al. Among authors: olsen ca. J Med Chem. 2016 Feb 11;59(3):1021-31. doi: 10.1021/acs.jmedchem.5b01532. Epub 2016 Jan 20. J Med Chem. 2016. PMID: 26788965

4

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.

Madsen AS, Andersen C, Daoud M, Anderson KA, Laursen JS, Chakladar S, Huynh FK, Colaço AR, Backos DS, Fristrup P, Hirschey MD, Olsen CA. Madsen AS, et al. Among authors: olsen ca. J Biol Chem. 2016 Mar 25;291(13):7128-41. doi: 10.1074/jbc.M115.668699. Epub 2016 Feb 9. J Biol Chem. 2016. PMID: 26861872 Free PMC article.

5

Innovative Strategies for Selective Inhibition of Histone Deacetylases.

Maolanon AR, Madsen AS, Olsen CA. Maolanon AR, et al. Among authors: olsen ca. Cell Chem Biol. 2016 Jul 21;23(7):759-768. doi: 10.1016/j.chembiol.2016.06.011. Cell Chem Biol. 2016. PMID: 27447046 Free article. Review.

6

Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities.

Kitir B, Maolanon AR, Ohm RG, Colaço AR, Fristrup P, Madsen AS, Olsen CA. Kitir B, et al. Among authors: olsen ca. Biochemistry. 2017 Sep 26;56(38):5134-5146. doi: 10.1021/acs.biochem.7b00725. Epub 2017 Sep 15. Biochemistry. 2017. PMID: 28858522

7

Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.

Rajabi N, Auth M, Troelsen KR, Pannek M, Bhatt DP, Fontenas M, Hirschey MD, Steegborn C, Madsen AS, Olsen CA. Rajabi N, et al. Among authors: olsen ca. Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14836-14841. doi: 10.1002/anie.201709050. Epub 2017 Nov 2. Angew Chem Int Ed Engl. 2017. PMID: 29044784 Free PMC article.

8

Targeting Sirtuins: Substrate Specificity and Inhibitor Design.

Rajabi N, Galleano I, Madsen AS, Olsen CA. Rajabi N, et al. Among authors: olsen ca. Prog Mol Biol Transl Sci. 2018;154:25-69. doi: 10.1016/bs.pmbts.2017.11.003. Prog Mol Biol Transl Sci. 2018. PMID: 29413177 Review.

9

Histone Deacetylase 11 Is an ε-N-Myristoyllysine Hydrolase.

Moreno-Yruela C, Galleano I, Madsen AS, Olsen CA. Moreno-Yruela C, et al. Among authors: olsen ca. Cell Chem Biol. 2018 Jul 19;25(7):849-856.e8. doi: 10.1016/j.chembiol.2018.04.007. Epub 2018 May 3. Cell Chem Biol. 2018. PMID: 29731425 Free article.

10

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression.

Moreno-Yruela C, Fass DM, Cheng C, Herz J, Olsen CA, Haggarty SJ. Moreno-Yruela C, et al. Among authors: olsen ca. ACS Chem Neurosci. 2019 Aug 21;10(8):3769-3777. doi: 10.1021/acschemneuro.9b00281. Epub 2019 Aug 5. ACS Chem Neurosci. 2019. PMID: 31330099 Free PMC article.

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