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Linking 7-Nitrobenzo-2-oxa-1,3-diazole (NBD) to Triphenylphosphonium Yields Mitochondria-Targeted Protonophore and Antibacterial Agent.
Iaubasarova IR, Khailova LS, Nazarov PA, Rokitskaya TI, Silachev DN, Danilina TI, Plotnikov EY, Denisov SS, Kirsanov RS, Korshunova GA, Kotova EA, Zorov DB, Antonenko YN. Iaubasarova IR, et al. Among authors: khailova ls. Biochemistry (Mosc). 2020 Dec;85(12):1578-1590. doi: 10.1134/S000629792012010X. Biochemistry (Mosc). 2020. PMID: 33705296
Tuning the hydrophobicity overcomes unfavorable deprotonation making octylamino-substituted 7-nitrobenz-2-oxa-1,3-diazole (n-octylamino-NBD) a protonophore and uncoupler of oxidative phosphorylation in mitochondria.
Denisov SS, Kotova EA, Khailova LS, Korshunova GA, Antonenko YN. Denisov SS, et al. Among authors: khailova ls. Bioelectrochemistry. 2014 Aug;98:30-8. doi: 10.1016/j.bioelechem.2014.02.002. Epub 2014 Mar 5. Bioelectrochemistry. 2014. PMID: 24650997
A long-linker conjugate of fluorescein and triphenylphosphonium as mitochondria-targeted uncoupler and fluorescent neuro- and nephroprotector.
Antonenko YN, Denisov SS, Silachev DN, Khailova LS, Jankauskas SS, Rokitskaya TI, Danilina TI, Kotova EA, Korshunova GA, Plotnikov EY, Zorov DB. Antonenko YN, et al. Among authors: khailova ls. Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2463-2473. doi: 10.1016/j.bbagen.2016.07.014. Epub 2016 Jul 20. Biochim Biophys Acta. 2016. PMID: 27450891
Alkyl-substituted phenylamino derivatives of 7-nitrobenz-2-oxa-1,3-diazole as uncouplers of oxidative phosphorylation and antibacterial agents: involvement of membrane proteins in the uncoupling action.
Antonenko YN, Denisov SS, Khailova LS, Nazarov PA, Rokitskaya T, Tashlitsky VN, Firsov AM, Korshunova GA, Kotova EA. Antonenko YN, et al. Among authors: khailova ls. Biochim Biophys Acta Biomembr. 2017 Mar;1859(3):377-387. doi: 10.1016/j.bbamem.2016.12.014. Epub 2016 Dec 21. Biochim Biophys Acta Biomembr. 2017. PMID: 28011176 Free article.
Antibiotic Pyrrolomycin as an Efficient Mitochondrial Uncoupler.
Firsov AM, Khailova LS, Rokitskaya TI, Kotova EA, Antonenko YN. Firsov AM, et al. Among authors: khailova ls. Biochemistry (Mosc). 2022 Aug;87(8):812-822. doi: 10.1134/S0006297922080120. Biochemistry (Mosc). 2022. PMID: 36171648
Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: synthesis and in vitro studies.
Antonenko YN, Avetisyan AV, Bakeeva LE, Chernyak BV, Chertkov VA, Domnina LV, Ivanova OY, Izyumov DS, Khailova LS, Klishin SS, Korshunova GA, Lyamzaev KG, Muntyan MS, Nepryakhina OK, Pashkovskaya AA, Pletjushkina OY, Pustovidko AV, Roginsky VA, Rokitskaya TI, Ruuge EK, Saprunova VB, Severina II, Simonyan RA, Skulachev IV, Skulachev MV, Sumbatyan NV, Sviryaeva IV, Tashlitsky VN, Vassiliev JM, Vyssokikh MY, Yaguzhinsky LS, Zamyatnin AA Jr, Skulachev VP. Antonenko YN, et al. Among authors: khailova ls. Biochemistry (Mosc). 2008 Dec;73(12):1273-87. doi: 10.1134/s0006297908120018. Biochemistry (Mosc). 2008. PMID: 19120014 Free article.
74 results