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Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.
Malik TH, Gitterman DP, Lavin DP, Lomax-Browne HJ, Hiemeyer EC, Moran LB, Boroviak K, Cook HT, Gilmore AC, Mandwie M, Ahmad A, Alexander IE, Logan GJ, Marchbank KJ, Bradley A, Pickering MC. Malik TH, et al. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2022722118. doi: 10.1073/pnas.2022722118. Proc Natl Acad Sci U S A. 2021. PMID: 33753502 Free PMC article.
A hybrid CFHR3-1 gene causes familial C3 glomerulopathy.
Malik TH, Lavin PJ, Goicoechea de Jorge E, Vernon KA, Rose KL, Patel MP, de Leeuw M, Neary JJ, Conlon PJ, Winn MP, Pickering MC. Malik TH, et al. J Am Soc Nephrol. 2012 Jul;23(7):1155-60. doi: 10.1681/ASN.2012020166. Epub 2012 May 24. J Am Soc Nephrol. 2012. PMID: 22626820 Free PMC article.
Dimerization of complement factor H-related proteins modulates complement activation in vivo.
Goicoechea de Jorge E, Caesar JJ, Malik TH, Patel M, Colledge M, Johnson S, Hakobyan S, Morgan BP, Harris CL, Pickering MC, Lea SM. Goicoechea de Jorge E, et al. Among authors: malik th. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4685-90. doi: 10.1073/pnas.1219260110. Epub 2013 Mar 4. Proc Natl Acad Sci U S A. 2013. PMID: 23487775 Free PMC article.
C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.
Tortajada A, Yébenes H, Abarrategui-Garrido C, Anter J, García-Fernández JM, Martínez-Barricarte R, Alba-Domínguez M, Malik TH, Bedoya R, Cabrera Pérez R, López Trascasa M, Pickering MC, Harris CL, Sánchez-Corral P, Llorca O, Rodríguez de Córdoba S. Tortajada A, et al. Among authors: malik th. J Clin Invest. 2013 Jun;123(6):2434-46. doi: 10.1172/JCI68280. J Clin Invest. 2013. PMID: 23728178 Free PMC article.
73 results