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Multi-Target Approaches in Metabolic Syndrome.
Lillich FF, Imig JD, Proschak E. Lillich FF, et al. Among authors: proschak e. Front Pharmacol. 2021 Mar 12;11:554961. doi: 10.3389/fphar.2020.554961. eCollection 2020. Front Pharmacol. 2021. PMID: 33776749 Free PMC article. Review.
Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ.
Göbel T, Diehl O, Heering J, Merk D, Angioni C, Wittmann SK, Buscato E, Kottke R, Weizel L, Schader T, Maier TJ, Geisslinger G, Schubert-Zsilavecz M, Steinhilber D, Proschak E, Kahnt AS. Göbel T, et al. Among authors: proschak e. Front Pharmacol. 2019 Mar 20;10:263. doi: 10.3389/fphar.2019.00263. eCollection 2019. Front Pharmacol. 2019. PMID: 30949053 Free PMC article.
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.
Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knöll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati GE, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E. Kramer JS, et al. Among authors: proschak e. J Med Chem. 2019 Sep 26;62(18):8443-8460. doi: 10.1021/acs.jmedchem.9b00445. Epub 2019 Sep 17. J Med Chem. 2019. PMID: 31436984 Free PMC article.
Dual soluble epoxide hydrolase inhibitor/PPAR-γ agonist attenuates renal fibrosis.
Stavniichuk A, Hye Khan MA, Yeboah MM, Chesnik MA, Jankiewicz WK, Hartmann M, Blöcher R, Kircher T, Savchuk O, Proschak E, Imig JD. Stavniichuk A, et al. Among authors: proschak e. Prostaglandins Other Lipid Mediat. 2020 Oct;150:106472. doi: 10.1016/j.prostaglandins.2020.106472. Epub 2020 Jun 20. Prostaglandins Other Lipid Mediat. 2020. PMID: 32569747
Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors.
Lillich FF, Willems S, Ni X, Kilu W, Borkowsky C, Brodsky M, Kramer JS, Brunst S, Hernandez-Olmos V, Heering J, Schierle S, Kestner RI, Mayser FM, Helmstädter M, Göbel T, Weizel L, Namgaladze D, Kaiser A, Steinhilber D, Pfeilschifter W, Kahnt AS, Proschak A, Chaikuad A, Knapp S, Merk D, Proschak E. Lillich FF, et al. Among authors: proschak a, proschak e. J Med Chem. 2021 Dec 9;64(23):17259-17276. doi: 10.1021/acs.jmedchem.1c01331. Epub 2021 Nov 24. J Med Chem. 2021. PMID: 34818007
DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells.
Seredinski S, Boos F, Günther S, Oo JA, Warwick T, Izquierdo Ponce J, Lillich FF, Proschak E, Knapp S, Gilsbach R, Pflüger-Müller B, Brandes RP, Leisegang MS. Seredinski S, et al. Among authors: proschak e. Mol Ther Nucleic Acids. 2022 Jan 25;27:1023-1035. doi: 10.1016/j.omtn.2022.01.016. eCollection 2022 Mar 8. Mol Ther Nucleic Acids. 2022. PMID: 35228897 Free PMC article.
Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells.
Brunst S, Schönfeld J, Breunig P, Burgers LD, DeMeglio M, Ehrler JHM, Lillich FF, Weizel L, Hefendehl JK, Fürst R, Proschak E, Hiesinger K. Brunst S, et al. Among authors: proschak e. ACS Med Chem Lett. 2022 Jun 14;13(7):1062-1067. doi: 10.1021/acsmedchemlett.2c00073. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859883 Free PMC article.
162 results