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Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research.
Crit Care Explor. 2021 Mar 12;3(3):e0374. doi: 10.1097/CCE.0000000000000374. eCollection 2021 Mar.
Crit Care Explor. 2021.
PMID: 33786450
Free PMC article.
Review.
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections.
Remy KE, Mazer M, Striker DA, Ellebedy AH, Walton AH, Unsinger J, Blood TM, Mudd PA, Yi DJ, Mannion DA, Osborne DF, Martin RS, Anand NJ, Bosanquet JP, Blood J, Drewry AM, Caldwell CC, Turnbull IR, Brakenridge SC, Moldwawer LL, Hotchkiss RS.
Remy KE, et al. Among authors: blood tm.
JCI Insight. 2020 Sep 3;5(17):e140329. doi: 10.1172/jci.insight.140329.
JCI Insight. 2020.
PMID: 32687484
Free PMC article.
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Frontline Science: OX40 agonistic antibody reverses immune suppression and improves survival in sepsis.
Unsinger J, Walton AH, Blood T, Tenney DJ, Quigley M, Drewry AM, Hotchkiss RS.
Unsinger J, et al.
J Leukoc Biol. 2021 Apr;109(4):697-708. doi: 10.1002/JLB.5HI0720-043R. Epub 2020 Aug 17.
J Leukoc Biol. 2021.
PMID: 33264454
Free PMC article.
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Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report.
Mazer MB, Turnbull IR, Miles S, Blood TM, Sadler B, Hess A, Botney MD, Martin RS, Bosanquet JP, Striker DA, Anand NS, Morre M, Caldwell CC, Brakenridge SC, Moldawer LL, Di Paola JA, Hotchkiss RS, Remy KE.
Mazer MB, et al. Among authors: blood tm.
Crit Care Explor. 2021 Jul 14;3(7):e0500. doi: 10.1097/CCE.0000000000000500. eCollection 2021 Jul.
Crit Care Explor. 2021.
PMID: 34345826
Free PMC article.
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Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial.
Daix T, Mathonnet A, Brakenridge S, Dequin PF, Mira JP, Berbille F, Morre M, Jeannet R, Blood T, Unsinger J, Blood J, Walton A, Moldawer LL, Hotchkiss R, François B.
Daix T, et al.
Ann Intensive Care. 2023 Mar 12;13(1):17. doi: 10.1186/s13613-023-01109-w.
Ann Intensive Care. 2023.
PMID: 36906875
Free PMC article.
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Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.
Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, Monneret G, Rimmelé T, Blood T, Morre M, Gregoire A, Mayo GA, Blood J, Durum SK, Sherwood ER, Hotchkiss RS.
Francois B, et al.
JCI Insight. 2018 Mar 8;3(5):e98960. doi: 10.1172/jci.insight.98960.
JCI Insight. 2018.
PMID: 29515037
Free PMC article.
Clinical Trial.
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Circulating human mononuclear cells exhibit augmented lysis of pig endothelium after activation with interleukin 2.
Itescu S, Kwiatkowski P, Wang SF, Blood T, Minanov OP, Rose S, Michler RE.
Itescu S, et al.
Transplantation. 1996 Dec 27;62(12):1927-33. doi: 10.1097/00007890-199612270-00043.
Transplantation. 1996.
PMID: 8990389
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