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Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α.
Chem Sci. 2023 Oct 27;14(43):12098-12120. doi: 10.1039/d3sc04253g. eCollection 2023 Nov 8.
Chem Sci. 2023.
PMID: 37969593
Free PMC article.
Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2.
Figg WD Jr, Fiorini G, Chowdhury R, Nakashima Y, Tumber A, McDonough MA, Schofield CJ.
Figg WD Jr, et al.
Proteins. 2023 Nov;91(11):1510-1524. doi: 10.1002/prot.26541. Epub 2023 Jul 14.
Proteins. 2023.
PMID: 37449559
Free PMC article.
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Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat.
Figg WD Jr, McDonough MA, Chowdhury R, Nakashima Y, Zhang Z, Holt-Martyn JP, Krajnc A, Schofield CJ.
Figg WD Jr, et al.
ChemMedChem. 2021 Jul 6;16(13):2082-2088. doi: 10.1002/cmdc.202100133. Epub 2021 Apr 9.
ChemMedChem. 2021.
PMID: 33792169
Free PMC article.
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Detectible mosaic truncating PPM1D mutations, age and breast cancer risk.
Machiela MJ, Myers TA, Lyons CJ, Koster R, Figg WD Jr, Colli LM, Jessop L, Ahearn TU, Freedman ND, García-Closas M, Chanock SJ.
Machiela MJ, et al. Among authors: figg wd jr.
J Hum Genet. 2019 Jun;64(6):545-550. doi: 10.1038/s10038-019-0589-1. Epub 2019 Mar 8.
J Hum Genet. 2019.
PMID: 30850729
Free PMC article.
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Association Between Thiopurine S-Methyltransferase (TPMT) Genetic Variants and Infection in Pediatric Heart Transplant Recipients Treated With Azathioprine: A Multi-Institutional Analysis.
Green DJ, Duong SQ, Burckart GJ, Sissung T, Price DK, Figg WD Jr, Brooks MM, Chinnock R, Canter C, Addonizio L, Bernstein D, Naftel DC, Zeevi A, Kirklin JK, Webber SA, Feingold B.
Green DJ, et al. Among authors: figg wd jr.
J Pediatr Pharmacol Ther. 2018 Mar-Apr;23(2):106-110. doi: 10.5863/1551-6776-23.2.106.
J Pediatr Pharmacol Ther. 2018.
PMID: 29720911
Free PMC article.
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