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Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome.
Liu X, Wang S, Guo X, Li Y, Ogurlu R, Lu F, Prondzynski M, de la Serna Buzon S, Ma Q, Zhang D, Wang G, Cotton J, Guo Y, Xiao L, Milan DJ, Xu Y, Schlame M, Bezzerides VJ, Pu WT. Liu X, et al. Among authors: prondzynski m. Circulation. 2021 May 11;143(19):1894-1911. doi: 10.1161/CIRCULATIONAHA.120.048698. Epub 2021 Apr 1. Circulation. 2021. PMID: 33793303 Free PMC article.
Gene therapy for inherited arrhythmias.
Bezzerides VJ, Prondzynski M, Carrier L, Pu WT. Bezzerides VJ, et al. Among authors: prondzynski m. Cardiovasc Res. 2020 Jul 15;116(9):1635-1650. doi: 10.1093/cvr/cvaa107. Cardiovasc Res. 2020. PMID: 32321160 Free PMC article. Review.
ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes.
Zech ATL, Prondzynski M, Singh SR, Pietsch N, Orthey E, Alizoti E, Busch J, Madsen A, Behrens CS, Meyer-Jens M, Mearini G, Lemoine MD, Krämer E, Mosqueira D, Virdi S, Indenbirken D, Depke M, Salazar MG, Völker U, Braren I, Pu WT, Eschenhagen T, Hammer E, Schlossarek S, Carrier L. Zech ATL, et al. Among authors: prondzynski m. Cells. 2022 Sep 2;11(17):2745. doi: 10.3390/cells11172745. Cells. 2022. PMID: 36078153 Free PMC article.
Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice.
Singh SR, Zech ATL, Geertz B, Reischmann-Düsener S, Osinska H, Prondzynski M, Krämer E, Meng Q, Redwood C, van der Velden J, Robbins J, Schlossarek S, Carrier L. Singh SR, et al. Among authors: prondzynski m. Circ Heart Fail. 2017 Oct;10(10):e004140. doi: 10.1161/CIRCHEARTFAILURE.117.004140. Circ Heart Fail. 2017. PMID: 29021349 Free PMC article.
Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca).
Horváth A, Christ T, Koivumäki JT, Prondzynski M, Zech ATL, Spohn M, Saleem U, Mannhardt I, Ulmer B, Girdauskas E, Meyer C, Hansen A, Eschenhagen T, Lemoine MD. Horváth A, et al. Among authors: prondzynski m. Cells. 2020 Jan 20;9(1):253. doi: 10.3390/cells9010253. Cells. 2020. PMID: 31968557 Free PMC article.
Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes.
Prondzynski M, Krämer E, Laufer SD, Shibamiya A, Pless O, Flenner F, Müller OJ, Münch J, Redwood C, Hansen A, Patten M, Eschenhagen T, Mearini G, Carrier L. Prondzynski M, et al. Mol Ther Nucleic Acids. 2017 Jun 16;7:475-486. doi: 10.1016/j.omtn.2017.05.008. Epub 2017 May 17. Mol Ther Nucleic Acids. 2017. PMID: 28624223 Free PMC article.
Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density.
Lemoine MD, Mannhardt I, Breckwoldt K, Prondzynski M, Flenner F, Ulmer B, Hirt MN, Neuber C, Horváth A, Kloth B, Reichenspurner H, Willems S, Hansen A, Eschenhagen T, Christ T. Lemoine MD, et al. Among authors: prondzynski m. Sci Rep. 2017 Jul 14;7(1):5464. doi: 10.1038/s41598-017-05600-w. Sci Rep. 2017. PMID: 28710467 Free PMC article.
CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy.
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A, Denning C. Mosqueira D, et al. Among authors: prondzynski m. Eur Heart J. 2018 Nov 14;39(43):3879-3892. doi: 10.1093/eurheartj/ehy249. Eur Heart J. 2018. PMID: 29741611 Free PMC article.
24 results