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Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery.
Huecas S, Araújo-Bazán L, Ruiz FM, Ruiz-Ávila LB, Martínez RF, Escobar-Peña A, Artola M, Vázquez-Villa H, Martín-Fontecha M, Fernández-Tornero C, López-Rodríguez ML, Andreu JM. Huecas S, et al. Among authors: artola m. J Med Chem. 2021 May 13;64(9):5730-5745. doi: 10.1021/acs.jmedchem.0c02207. Epub 2021 Apr 28. J Med Chem. 2021. PMID: 33908781 Free PMC article.
Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases.
van der Gracht D, Rowland RJ, Roig-Zamboni V, Ferraz MJ, Louwerse M, Geurink PP, Aerts JMFG, Sulzenbacher G, Davies GJ, Overkleeft HS, Artola M. van der Gracht D, et al. Among authors: artola m. Chem Sci. 2023 Aug 8;14(34):9136-9144. doi: 10.1039/d3sc01021j. eCollection 2023 Aug 30. Chem Sci. 2023. PMID: 37655021 Free PMC article.
New synthetic inhibitors of fatty acid synthase with anticancer activity.
Turrado C, Puig T, García-Cárceles J, Artola M, Benhamú B, Ortega-Gutiérrez S, Relat J, Oliveras G, Blancafort A, Haro D, Marrero PF, Colomer R, López-Rodríguez ML. Turrado C, et al. Among authors: artola m. J Med Chem. 2012 Jun 14;55(11):5013-23. doi: 10.1021/jm2016045. Epub 2012 May 16. J Med Chem. 2012. PMID: 22559865
Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.
Ruiz-Avila LB, Huecas S, Artola M, Vergoñós A, Ramírez-Aportela E, Cercenado E, Barasoain I, Vázquez-Villa H, Martín-Fontecha M, Chacón P, López-Rodríguez ML, Andreu JM. Ruiz-Avila LB, et al. Among authors: artola m. ACS Chem Biol. 2013 Sep 20;8(9):2072-83. doi: 10.1021/cb400208z. Epub 2013 Jul 31. ACS Chem Biol. 2013. PMID: 23855511
Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action.
Artola M, Ruiz-Avila LB, Vergoñós A, Huecas S, Araujo-Bazán L, Martín-Fontecha M, Vázquez-Villa H, Turrado C, Ramírez-Aportela E, Hoegl A, Nodwell M, Barasoain I, Chacón P, Sieber SA, Andreu JM, López-Rodríguez ML. Artola M, et al. ACS Chem Biol. 2015 Mar 20;10(3):834-43. doi: 10.1021/cb500974d. Epub 2014 Dec 30. ACS Chem Biol. 2015. PMID: 25486266
Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer.
Pérez-Gómez E, Andradas C, Blasco-Benito S, Caffarel MM, García-Taboada E, Villa-Morales M, Moreno E, Hamann S, Martín-Villar E, Flores JM, Wenners A, Alkatout I, Klapper W, Röcken C, Bronsert P, Stickeler E, Staebler A, Bauer M, Arnold N, Soriano J, Pérez-Martínez M, Megías D, Moreno-Bueno G, Ortega-Gutiérrez S, Artola M, Vázquez-Villa H, Quintanilla M, Fernández-Piqueras J, Canela EI, McCormick PJ, Guzmán M, Sánchez C. Pérez-Gómez E, et al. Among authors: artola m. J Natl Cancer Inst. 2015 Apr 8;107(6):djv077. doi: 10.1093/jnci/djv077. Print 2015 Jun. J Natl Cancer Inst. 2015. PMID: 25855725 Free article.
Identification of a novel orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor with efficacy in animal models of schizophrenia.
Bartolomé-Nebreda JM, Alonso de Diego SA, Artola M, Delgado F, Delgado Ó, Martín-Martín ML, Martínez-Viturro CM, Pena MÁ, Tong HM, Van Gool M, Alonso JM, Fontana A, Macdonald GJ, Megens A, Langlois X, Somers M, Vanhoof G, Conde-Ceide S. Bartolomé-Nebreda JM, et al. Among authors: artola m. J Med Chem. 2015 Jan 22;58(2):978-93. doi: 10.1021/jm501651a. Epub 2015 Jan 12. J Med Chem. 2015. PMID: 25495129
63 results