Kaczmarski JA - Search Results

1

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity.

Izoré T, Candace Ho YT, Kaczmarski JA, Gavriilidou A, Chow KH, Steer DL, Goode RJA, Schittenhelm RB, Tailhades J, Tosin M, Challis GL, Krenske EH, Ziemert N, Jackson CJ, Cryle MJ. Izoré T, et al. Among authors: kaczmarski ja. Nat Commun. 2021 May 4;12(1):2511. doi: 10.1038/s41467-021-22623-0. Nat Commun. 2021. PMID: 33947858 Free PMC article.

2

Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein.

Clifton BE, Kaczmarski JA, Carr PD, Gerth ML, Tokuriki N, Jackson CJ. Clifton BE, et al. Among authors: kaczmarski ja. Nat Chem Biol. 2018 Jun;14(6):542-547. doi: 10.1038/s41589-018-0043-2. Epub 2018 Apr 23. Nat Chem Biol. 2018. PMID: 29686357

3

Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain.

Izoré T, Tailhades J, Hansen MH, Kaczmarski JA, Jackson CJ, Cryle MJ. Izoré T, et al. Among authors: kaczmarski ja. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2913-2918. doi: 10.1073/pnas.1811194116. Epub 2019 Jan 31. Proc Natl Acad Sci U S A. 2019. PMID: 30705105 Free PMC article.

4

Structural and evolutionary approaches to the design and optimization of fluorescence-based small molecule biosensors.

Kaczmarski JA, Mitchell JA, Spence MA, Vongsouthi V, Jackson CJ. Kaczmarski JA, et al. Curr Opin Struct Biol. 2019 Aug;57:31-38. doi: 10.1016/j.sbi.2019.01.013. Epub 2019 Feb 27. Curr Opin Struct Biol. 2019. PMID: 30825845 Review.

5

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics.

Greule A, Izoré T, Iftime D, Tailhades J, Schoppet M, Zhao Y, Peschke M, Ahmed I, Kulik A, Adamek M, Goode RJA, Schittenhelm RB, Kaczmarski JA, Jackson CJ, Ziemert N, Krenske EH, De Voss JJ, Stegmann E, Cryle MJ. Greule A, et al. Among authors: kaczmarski ja. Nat Commun. 2019 Jun 13;10(1):2613. doi: 10.1038/s41467-019-10384-w. Nat Commun. 2019. PMID: 31197182 Free PMC article.

6

Structural Basis for the Allosteric Regulation of the SbtA Bicarbonate Transporter by the P_II-like Protein, SbtB, from Cyanobium sp. PCC7001.

Kaczmarski JA, Hong NS, Mukherjee B, Wey LT, Rourke L, Förster B, Peat TS, Price GD, Jackson CJ. Kaczmarski JA, et al. Biochemistry. 2019 Dec 17;58(50):5030-5039. doi: 10.1021/acs.biochem.9b00880. Epub 2019 Dec 3. Biochemistry. 2019. PMID: 31746199

7

Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme.

Kaczmarski JA, Mahawaththa MC, Feintuch A, Clifton BE, Adams LA, Goldfarb D, Otting G, Jackson CJ. Kaczmarski JA, et al. Nat Commun. 2020 Nov 23;11(1):5945. doi: 10.1038/s41467-020-19695-9. Nat Commun. 2020. PMID: 33230119 Free PMC article.

8

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes.

Chatterjee D, Lewis FJ, Sutton HJ, Kaczmarski JA, Gao X, Cai Y, McNamara HA, Jackson CJ, Cockburn IA. Chatterjee D, et al. Among authors: kaczmarski ja. Cell Rep. 2021 Apr 13;35(2):108996. doi: 10.1016/j.celrep.2021.108996. Cell Rep. 2021. PMID: 33852850 Free PMC article.

9

Ancestral sequence reconstruction for protein engineers.

Spence MA, Kaczmarski JA, Saunders JW, Jackson CJ. Spence MA, et al. Among authors: kaczmarski ja. Curr Opin Struct Biol. 2021 Aug;69:131-141. doi: 10.1016/j.sbi.2021.04.001. Epub 2021 May 21. Curr Opin Struct Biol. 2021. PMID: 34023793 Review.

10

Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming.

Ford DJ, Duggan NM, Fry SE, Ripoll-Rozada J, Agten SM, Liu W, Corcilius L, Hackeng TM, van Oerle R, Spronk HMH, Ashhurst AS, Mini Sasi V, Kaczmarski JA, Jackson CJ, Pereira PJB, Passioura T, Suga H, Payne RJ. Ford DJ, et al. Among authors: kaczmarski ja. J Med Chem. 2021 Jun 10;64(11):7853-7876. doi: 10.1021/acs.jmedchem.1c00651. Epub 2021 May 27. J Med Chem. 2021. PMID: 34044534

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