Ziehm T - Search Results

1

Effects of a Multimerized Recombinant Autoantibody Against Amyloid-β.

Albus A, Kronimus Y, Neumann S, Vidovic N, Frenzel A, Kuhn P, Seifert M, Ziehm T, van der Wurp H, Dodel R. Albus A, et al. Among authors: ziehm t. Neuroscience. 2021 May 21;463:355-369. doi: 10.1016/j.neuroscience.2021.03.006. Epub 2021 Apr 12. Neuroscience. 2021. PMID: 33958140

2

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

Ziehm T, Brener O, van Groen T, Kadish I, Frenzel D, Tusche M, Kutzsche J, Reiß K, Gremer L, Nagel-Steger L, Willbold D. Ziehm T, et al. ACS Chem Neurosci. 2016 Aug 17;7(8):1088-96. doi: 10.1021/acschemneuro.6b00047. Epub 2016 Jun 9. ACS Chem Neurosci. 2016. PMID: 27240424

3

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

Klein AN, Ziehm T, van Groen T, Kadish I, Elfgen A, Tusche M, Thomaier M, Reiss K, Brener O, Gremer L, Kutzsche J, Willbold D. Klein AN, et al. Among authors: ziehm t. ACS Chem Neurosci. 2017 Sep 20;8(9):1889-1900. doi: 10.1021/acschemneuro.7b00045. Epub 2017 Jun 23. ACS Chem Neurosci. 2017. PMID: 28581708

4

Role of Hydrophobicity and Charge of Amyloid-Beta Oligomer Eliminating d-Peptides in the Interaction with Amyloid-Beta Monomers.

Ziehm T, Buell AK, Willbold D. Ziehm T, et al. ACS Chem Neurosci. 2018 Nov 21;9(11):2679-2688. doi: 10.1021/acschemneuro.8b00132. Epub 2018 Jun 21. ACS Chem Neurosci. 2018. PMID: 29893543

5

The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson's Disease.

Albus A, Kronimus Y, Burg-Roderfeld M, van der Wurp H, Willbold D, Ziehm T, Dodel R, Ross JA. Albus A, et al. Among authors: ziehm t. Biomolecules. 2023 Aug 25;13(9):1303. doi: 10.3390/biom13091303. Biomolecules. 2023. PMID: 37759704 Free PMC article.

6

Pharmacokinetic Properties of a Novel D-Peptide Developed to be Therapeutically Active Against Toxic β-Amyloid Oligomers.

Leithold LH, Jiang N, Post J, Ziehm T, Schartmann E, Kutzsche J, Shah NJ, Breitkreutz J, Langen KJ, Willuweit A, Willbold D. Leithold LH, et al. Among authors: ziehm t. Pharm Res. 2016 Feb;33(2):328-36. doi: 10.1007/s11095-015-1791-2. Epub 2015 Sep 17. Pharm Res. 2016. PMID: 26381279

7

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.

van Groen T, Schemmert S, Brener O, Gremer L, Ziehm T, Tusche M, Nagel-Steger L, Kadish I, Schartmann E, Elfgen A, Jürgens D, Willuweit A, Kutzsche J, Willbold D. van Groen T, et al. Among authors: ziehm t. Sci Rep. 2017 Nov 24;7(1):16275. doi: 10.1038/s41598-017-16565-1. Sci Rep. 2017. PMID: 29176708 Free PMC article.

8

Comparison of blood-brain barrier penetration efficiencies between linear and cyclic all-d-enantiomeric peptides developed for the treatment of Alzheimer's disease.

Schartmann E, Schemmert S, Ziehm T, Leithold LHE, Jiang N, Tusche M, Joni Shah N, Langen KJ, Kutzsche J, Willbold D, Willuweit A. Schartmann E, et al. Among authors: ziehm t. Eur J Pharm Sci. 2018 Mar 1;114:93-102. doi: 10.1016/j.ejps.2017.12.005. Epub 2017 Dec 7. Eur J Pharm Sci. 2018. PMID: 29225107

9

Aβ oligomer eliminating compounds interfere successfully with pEAβ(3-42) induced motor neurodegenerative phenotype in transgenic mice.

Dunkelmann T, Teichmann K, Ziehm T, Schemmert S, Frenzel D, Tusche M, Dammers C, Jürgens D, Langen KJ, Demuth HU, Shah NJ, Kutzsche J, Willuweit A, Willbold D. Dunkelmann T, et al. Among authors: ziehm t. Neuropeptides. 2018 Feb;67:27-35. doi: 10.1016/j.npep.2017.11.011. Epub 2017 Nov 27. Neuropeptides. 2018. PMID: 29273382

10

Relevance of N-terminal residues for amyloid-β binding to platelet integrin α_IIbβ₃, integrin outside-in signaling and amyloid-β fibril formation.

Donner L, Gremer L, Ziehm T, Gertzen CGW, Gohlke H, Willbold D, Elvers M. Donner L, et al. Among authors: ziehm t. Cell Signal. 2018 Oct;50:121-130. doi: 10.1016/j.cellsig.2018.06.015. Epub 2018 Jun 30. Cell Signal. 2018. PMID: 29964150

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