Monia BP - Search Results

1

An oral antisense oligonucleotide for PCSK9 inhibition.

Gennemark P, Walter K, Clemmensen N, Rekić D, Nilsson CAM, Knöchel J, Hölttä M, Wernevik L, Rosengren B, Kakol-Palm D, Wang Y, Yu RZ, Geary RS, Riney SJ, Monia BP, Isaksson R, Jansson-Löfmark R, Rocha CSJ, Lindén D, Hurt-Camejo E, Crooke R, Tillman L, Rydén-Bergsten T, Carlsson B, Andersson U, Elebring M, Tivesten A, Davies N. Gennemark P, et al. Among authors: monia bp. Sci Transl Med. 2021 May 12;13(593):eabe9117. doi: 10.1126/scitranslmed.abe9117. Sci Transl Med. 2021. PMID: 33980578

2

Immunogenicity Assessment of Inotersen, a 2'-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety.

Yu RZ, Wang Y, Norris DA, Kim TW, Narayanan P, Geary RS, Monia BP, Henry SP. Yu RZ, et al. Among authors: monia bp. Nucleic Acid Ther. 2020 Oct;30(5):265-275. doi: 10.1089/nat.2020.0867. Epub 2020 Aug 19. Nucleic Acid Ther. 2020. PMID: 32833564 Clinical Trial.

3

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data.

Viney NJ, Guo S, Tai LJ, Baker BF, Aghajan M, Jung SW, Yu RZ, Booten S, Murray H, Machemer T, Burel S, Murray S, Buchele G, Tsimikas S, Schneider E, Geary RS, Benson MD, Monia BP. Viney NJ, et al. Among authors: monia bp. ESC Heart Fail. 2021 Feb;8(1):652-661. doi: 10.1002/ehf2.13154. Epub 2020 Dec 7. ESC Heart Fail. 2021. PMID: 33283485 Free PMC article. Clinical Trial.

4

Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice.

Graham MJ, Lemonidis KM, Whipple CP, Subramaniam A, Monia BP, Crooke ST, Crooke RM. Graham MJ, et al. Among authors: monia bp. J Lipid Res. 2007 Apr;48(4):763-7. doi: 10.1194/jlr.C600025-JLR200. Epub 2007 Jan 22. J Lipid Res. 2007. PMID: 17242417 Free article.

5

Population Pharmacokinetic-Pharmacodynamic Modeling of Inotersen, an Antisense Oligonucleotide for Treatment of Patients with Hereditary Transthyretin Amyloidosis.

Yu RZ, Collins JW, Hall S, Ackermann EJ, Geary RS, Monia BP, Henry SP, Wang Y. Yu RZ, et al. Among authors: monia bp. Nucleic Acid Ther. 2020 Jun;30(3):153-163. doi: 10.1089/nat.2019.0822. Epub 2020 Apr 15. Nucleic Acid Ther. 2020. PMID: 32286934 Free PMC article. Clinical Trial.

6

Population pharmacokinetic/pharmacodynamic modelling of eplontersen, an antisense oligonucleotide in development for transthyretin amyloidosis.

Diep JK, Yu RZ, Viney NJ, Schneider E, Guo S, Henry S, Monia B, Geary R, Wang Y. Diep JK, et al. Br J Clin Pharmacol. 2022 Dec;88(12):5389-5398. doi: 10.1111/bcp.15468. Epub 2022 Aug 7. Br J Clin Pharmacol. 2022. PMID: 35869634 Free article.

7

Anti-inflammatory activity of inhaled IL-4 receptor-alpha antisense oligonucleotide in mice.

Karras JG, Crosby JR, Guha M, Tung D, Miller DA, Gaarde WA, Geary RS, Monia BP, Gregory SA. Karras JG, et al. Among authors: monia bp. Am J Respir Cell Mol Biol. 2007 Mar;36(3):276-85. doi: 10.1165/rcmb.2005-0456OC. Epub 2006 Sep 21. Am J Respir Cell Mol Biol. 2007. PMID: 16990616

8

Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS.

Ross SJ, Revenko AS, Hanson LL, Ellston R, Staniszewska A, Whalley N, Pandey SK, Revill M, Rooney C, Buckett LK, Klein SK, Hudson K, Monia BP, Zinda M, Blakey DC, Lyne PD, Macleod AR. Ross SJ, et al. Among authors: monia bp. Sci Transl Med. 2017 Jun 14;9(394):eaal5253. doi: 10.1126/scitranslmed.aal5253. Sci Transl Med. 2017. PMID: 28615361

9

Inhaled CD86 antisense oligonucleotide suppresses pulmonary inflammation and airway hyper-responsiveness in allergic mice.

Crosby JR, Guha M, Tung D, Miller DA, Bender B, Condon TP, York-DeFalco C, Geary RS, Monia BP, Karras JG, Gregory SA. Crosby JR, et al. Among authors: monia bp. J Pharmacol Exp Ther. 2007 Jun;321(3):938-46. doi: 10.1124/jpet.106.119214. Epub 2007 Mar 26. J Pharmacol Exp Ther. 2007. PMID: 17389243

10

Preclinical evaluation of the effects of a novel antisense compound targeting C-raf kinase in mice and monkeys.

Monteith DK, Geary RS, Leeds JM, Johnston J, Monia BP, Levin AA. Monteith DK, et al. Among authors: monia bp. Toxicol Sci. 1998 Dec;46(2):365-75. doi: 10.1006/toxs.1998.2527. Toxicol Sci. 1998. PMID: 10048140

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