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Page 1
Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.
Ashton TD, Calic PPS, Dans MG, Ooi ZK, Zhou Q, Loi K, Jarman KE, Palandri J, Qiu D, Lehane AM, Maity B, De N, Famodimu MT, Delves MJ, Mao EY, Gancheva MR, Wilson DW, Chowdury M, de Koning-Ward TF, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Ashton TD, et al. Among authors: lehane am. ChemMedChem. 2024 Aug 30:e202400549. doi: 10.1002/cmdc.202400549. Online ahead of print. ChemMedChem. 2024. PMID: 39210733
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.
Ashton TD, Calic PPS, Dans MG, Ooi ZK, Zhou Q, Palandri J, Loi K, Jarman KE, Qiu D, Lehane AM, Maity BC, De N, Giannangelo C, MacRaild CA, Creek DJ, Mao EY, Gancheva MR, Wilson DW, Chowdury M, de Koning-Ward TF, Famodimu MT, Delves MJ, Pollard H, Sutherland CJ, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Ashton TD, et al. Among authors: lehane am. J Med Chem. 2024 Aug 22;67(16):14493-14523. doi: 10.1021/acs.jmedchem.4c01241. Epub 2024 Aug 12. J Med Chem. 2024. PMID: 39134060 Free PMC article.
Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.
Calic PPS, Ashton TD, Mansouri M, Loi K, Jarman KE, Qiu D, Lehane AM, Roy S, Rao GP, Maity B, Wittlin S, Crespo B, Gamo FJ, Deni I, Fidock DA, Chowdury M, de Koning-Ward TF, Cowman AF, Jackson PF, Baud D, Brand S, Laleu B, Sleebs BE. Calic PPS, et al. Among authors: lehane am. Eur J Med Chem. 2024 Oct 5;276:116677. doi: 10.1016/j.ejmech.2024.116677. Epub 2024 Jul 14. Eur J Med Chem. 2024. PMID: 39024967 Free article.
Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides.
Redway A, Spry C, Brown A, Wiedemann U, Fathoni I, Garnie LF, Qiu D, Egan TJ, Lehane AM, Jackson Y, Saliba KJ, Downer-Riley N. Redway A, et al. Among authors: lehane am. Int J Parasitol Drugs Drug Resist. 2024 Aug;25:100536. doi: 10.1016/j.ijpddr.2024.100536. Epub 2024 Apr 3. Int J Parasitol Drugs Drug Resist. 2024. PMID: 38663046 Free PMC article.
Pediatric and Young Adult Trauma Recidivism.
Lehane A, Wood E, Pranikoff S, Avery M, Pranikoff T. Lehane A, et al. Am Surg. 2024 Sep;90(9):2182-2187. doi: 10.1177/00031348241248698. Epub 2024 Apr 23. Am Surg. 2024. PMID: 38653577
64 results