Structure basis for the inhibitory mechanism of a novel DNase gamma-specific inhibitor, DR396.
Sunaga S, Yoshimori A, Shiokawa D, Tanuma S.
Sunaga S, et al. Among authors: yoshimori a.
Bioorg Med Chem. 2006 Jun 15;14(12):4217-26. doi: 10.1016/j.bmc.2006.01.073. Epub 2006 Mar 29.
Bioorg Med Chem. 2006.
PMID: 16574417
DNase gamma, a member of the DNase I family, has been suggested to cause DNA fragmentation during apoptosis. We recently identified 4-(4,6-dichloro-[1,3,5]-triazine-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid (DR396) as a novel specific inhibitor for …
DNase gamma, a member of the DNase I family, has been suggested to cause DNA fragmentation during apoptosis. We recently identified 4 …