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Phase 1 Study of the Anti-HtrA1 Antibody-binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-related Macular Degeneration.
Khanani AM, Hershberger VS, Pieramici DJ, Khurana RN, Brunstein F, Ma L, Maass KF, Honigberg LA, Tom I, Chen H, Strauss EC, Lai P; Phase I Investigators. Khanani AM, et al. Among authors: tom i. Am J Ophthalmol. 2021 Dec;232:49-57. doi: 10.1016/j.ajo.2021.06.017. Epub 2021 Jun 29. Am J Ophthalmol. 2021. PMID: 34214452 Free article. Clinical Trial.
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy.
Tom I, Pham VC, Katschke KJ Jr, Li W, Liang WC, Gutierrez J, Ah Young A, Figueroa I, Eshghi ST, Lee CV, Kanodia J, Snipas SJ, Salvesen GS, Lai P, Honigberg L, van Lookeren Campagne M, Kirchhofer D, Baruch A, Lill JR. Tom I, et al. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9952-9963. doi: 10.1073/pnas.1917608117. Epub 2020 Apr 28. Proc Natl Acad Sci U S A. 2020. PMID: 32345717 Free PMC article.
33 results