Strong K - Search Results

1

Recurrent seizure-related GRIN1 variant: Molecular mechanism and targeted therapy.

Xu Y, Song R, Chen W, Strong K, Shrey D, Gedela S, Traynelis SF, Zhang G, Yuan H. Xu Y, et al. Among authors: strong k. Ann Clin Transl Neurol. 2021 Jul;8(7):1480-1494. doi: 10.1002/acn3.51406. Epub 2021 Jul 6. Ann Clin Transl Neurol. 2021. PMID: 34227748 Free PMC article.

2

Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors.

Santangelo Freel RM, Ogden KK, Strong KL, Khatri A, Chepiga KM, Jensen HS, Traynelis SF, Liotta DC. Santangelo Freel RM, et al. Among authors: strong kl. J Med Chem. 2013 Jul 11;56(13):5351-81. doi: 10.1021/jm400177t. Epub 2013 Jun 20. J Med Chem. 2013. PMID: 23627311 Free PMC article.

3

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains.

Swanger SA, Chen W, Wells G, Burger PB, Tankovic A, Bhattacharya S, Strong KL, Hu C, Kusumoto H, Zhang J, Adams DR, Millichap JJ, Petrovski S, Traynelis SF, Yuan H. Swanger SA, et al. Am J Hum Genet. 2016 Dec 1;99(6):1261-1280. doi: 10.1016/j.ajhg.2016.10.002. Epub 2016 Nov 10. Am J Hum Genet. 2016. PMID: 27839871 Free PMC article.

4

Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-d-Aspartate (NMDA) Receptor.

Epplin MP, Mohan A, Harris LD, Zhu Z, Strong KL, Bacsa J, Le P, Menaldino DS, Traynelis SF, Liotta DC. Epplin MP, et al. J Med Chem. 2020 Jul 23;63(14):7569-7600. doi: 10.1021/acs.jmedchem.9b01733. Epub 2020 Jul 6. J Med Chem. 2020. PMID: 32538088 Free PMC article.

5

Novel NMDA receptor modulators: an update.

Santangelo RM, Acker TM, Zimmerman SS, Katzman BM, Strong KL, Traynelis SF, Liotta DC. Santangelo RM, et al. Expert Opin Ther Pat. 2012 Nov;22(11):1337-52. doi: 10.1517/13543776.2012.728587. Epub 2012 Sep 26. Expert Opin Ther Pat. 2012. PMID: 23009122 Free PMC article. Review.

6

NMDA receptor modulators: an updated patent review (2013-2014).

Strong KL, Jing Y, Prosser AR, Traynelis SF, Liotta DC. Strong KL, et al. Expert Opin Ther Pat. 2014 Dec;24(12):1349-66. doi: 10.1517/13543776.2014.972938. Epub 2014 Oct 29. Expert Opin Ther Pat. 2014. PMID: 25351527 Free PMC article. Review.

7

The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.

Strong KL, Epplin MP, Bacsa J, Butch CJ, Burger PB, Menaldino DS, Traynelis SF, Liotta DC. Strong KL, et al. J Med Chem. 2017 Jul 13;60(13):5556-5585. doi: 10.1021/acs.jmedchem.7b00239. Epub 2017 Jun 26. J Med Chem. 2017. PMID: 28586221 Free PMC article.

8

The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor.

Kaiser TM, Kell SA, Kusumoto H, Shaulsky G, Bhattacharya S, Epplin MP, Strong KL, Miller EJ, Cox BD, Menaldino DS, Liotta DC, Traynelis SF, Burger PB. Kaiser TM, et al. Mol Pharmacol. 2018 Feb;93(2):141-156. doi: 10.1124/mol.117.110940. Epub 2017 Dec 14. Mol Pharmacol. 2018. PMID: 29242355 Free PMC article.

9

Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors.

Strong KL, Epplin MP, Ogden KK, Burger PB, Kaiser TM, Wilding TJ, Kusumoto H, Camp CR, Shaulsky G, Bhattacharya S, Perszyk RE, Menaldino DS, McDaniel MJ, Zhang J, Le P, Banke TG, Hansen KB, Huettner JE, Liotta DC, Traynelis SF. Strong KL, et al. ACS Chem Neurosci. 2021 Jan 6;12(1):79-98. doi: 10.1021/acschemneuro.0c00561. Epub 2020 Dec 16. ACS Chem Neurosci. 2021. PMID: 33326224 Free PMC article.

10

GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity.

Perszyk RE, DiRaddo JO, Strong KL, Low CM, Ogden KK, Khatri A, Vargish GA, Pelkey KA, Tricoire L, Liotta DC, Smith Y, McBain CJ, Traynelis SF. Perszyk RE, et al. Among authors: strong kl. Mol Pharmacol. 2016 Dec;90(6):689-702. doi: 10.1124/mol.116.105130. Epub 2016 Sep 13. Mol Pharmacol. 2016. PMID: 27625038 Free PMC article.

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