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Granzyme K drives a newly-intentified pathway of complement activation.
Donado CA, Jonsson AH, Theisen E, Zhang F, Nathan A, Rupani KV, Jones D; Accelerating Medicines Partnership RA/SLE Network; Raychaudhuri S, Dwyer DF, Brenner MB. Donado CA, et al. bioRxiv [Preprint]. 2024 May 26:2024.05.22.595315. doi: 10.1101/2024.05.22.595315. bioRxiv. 2024. PMID: 38826230 Free PMC article. Preprint.
Here, we show that GZMK can activate the complement cascade by cleaving C2 and C4. The nascent C4b and C2a fragments form a C3 convertase that cleaves C3, allowing further assembly of a C5 convertase that cleaves C5. The resulting convertases trigger every major eve …
Here, we show that GZMK can activate the complement cascade by cleaving C2 and C4. The nascent C4b and C2a fragments form a C3 conver …
New Classification of Rheumatoid Arthritis Based on Immune Cells and Clinical Characteristics.
Wang J, Xue Y, Zhou L. Wang J, et al. J Inflamm Res. 2024 May 22;17:3293-3305. doi: 10.2147/JIR.S395566. eCollection 2024. J Inflamm Res. 2024. PMID: 38800595 Free PMC article.
Subsequently, we classified RA into three subtypes by unsupervised clustering of serum gene expression profiles based on immune enrichment scores. ...CONCLUSION: In this study, RA patients were divided into different immune molecular subtypes based on gene expressio …
Subsequently, we classified RA into three subtypes by unsupervised clustering of serum gene expression profiles based on immune enric …
The fibroid phenotype of biological naïve patients with rheumatoid arthritis are less likely to respond to anti-IL-6R treatment.
Madsen SF, Sinkeviciute D, Thudium CS, Karsdal MA, Bay-Jensen AC. Madsen SF, et al. Sci Rep. 2024 May 10;14(1):10751. doi: 10.1038/s41598-024-61435-2. Sci Rep. 2024. PMID: 38730088 Free PMC article.
In this exploratory study, we aimed to investigate the association between fibrogenesis (PRO-C3) and the disease- and treatment response in patients with RA. ...This showed that a reduction in PRO-C3 after treatment initiation was associated with decreased DA …
In this exploratory study, we aimed to investigate the association between fibrogenesis (PRO-C3) and the disease- and treatment respo …
A large cohort comparison of very late-onset systemic lupus erythematosus with younger-onset patients.
Viveiros L, Neves A, Gouveia T, Isenberg DA. Viveiros L, et al. Clin Exp Rheumatol. 2024 Mar 19. doi: 10.55563/clinexprheumatol/jgsyos. Online ahead of print. Clin Exp Rheumatol. 2024. PMID: 38526004
The vlSLE group tended to have a lower female-to-male ratio (4:1; p=0.282), was mainly Caucasian (93.3%; p<0.001), and had the lowest survival time (20.3 years; p<0.001). vlSLE patients had the lowest prevalence of positive anti-dsDNA antibodies (26.7%; p=0.010) and low …
The vlSLE group tended to have a lower female-to-male ratio (4:1; p=0.282), was mainly Caucasian (93.3%; p<0.001), and had the lowest sur …
Personalized cardiovascular risk assessment in Rheumatoid Arthritis patients using circulating molecular profiles and their modulation by TNFi, IL6Ri, and JAKinibs.
Muñoz-Barrera L, Perez-Sanchez C, Ortega-Castro R, Corrales S, Luque-Tevar M, Cerdó T, Sanchez-Pareja I, Font P, Lopez-Mejías R, Calvo J, Abalos-Aguilera MC, Ruiz-Vilchez D, Segui P, Merlo C, Perez-Venegas J, Ruiz Montesino MD, Rodriguez-Escalera C, Barco CR, Fernandez-Nebro A, Vazque NM, Marenco JL, Montañes JU, Godoy-Navarrete J, Cabezas-Lucena AM, Estevez EC, Aguirre MA, González-Gay MA, Barbarroja N, Escudero-Contreras A, Lopez-Pedrera C. Muñoz-Barrera L, et al. Biomed Pharmacother. 2024 Apr;173:116357. doi: 10.1016/j.biopha.2024.116357. Epub 2024 Mar 12. Biomed Pharmacother. 2024. PMID: 38479179 Free article.
PATIENTS & METHODS: A total of 387 RA patients and 45 healthy donors were recruited, forming three cohorts: i) 208 RA patients with established disease but without previous CV events; ii) RA-CVD: 96 RA patients with CV events, and iii) 83 RA …
PATIENTS & METHODS: A total of 387 RA patients and 45 healthy donors were recruited, forming three cohorts: i) 208 RA pati …
Vertical Relationship Ratio (VRR): A High Reliability and Accuracy Radiographic Measurement for Basilar Invagination in Rheumatoid Arthritis.
Ruangchainikom M, Korwutthikulrangsri E, Rattanatanasarn A, Kanjanakeereewong I, Boonsirikamchai W, Tirawanish P, Thanapipatsiri S, Sutipornpalangkul W. Ruangchainikom M, et al. Med Sci Monit. 2024 Feb 18;30:e943329. doi: 10.12659/MSM.943329. Med Sci Monit. 2024. PMID: 38368505 Free PMC article.
The VRR is the relationship between the distance obtained with the modified Ranawat method and the C3 vertebral body height. VRR was used to assess its ability to distinguish BI in 3 patient groups (28 RA with BI, 37 RA without BI, and 56 non-RA patien …
The VRR is the relationship between the distance obtained with the modified Ranawat method and the C3 vertebral body height. VRR was …
Management of acute breakthrough hemolysis with intensive pegcetacoplan dosing in patients with PNH.
Griffin M, Kelly RJ, Panse J, de Castro C, Szer J, Horneff R, Tan L, Yeh M, Peffault de Latour R. Griffin M, et al. Blood Adv. 2024 Apr 9;8(7):1776-1786. doi: 10.1182/bloodadvances.2023011691. Blood Adv. 2024. PMID: 38315872 Free PMC article.
Breakthrough hemolysis (BTH) was first described in patients with PNH treated with terminal complement C5 inhibitors when intravascular hemolysis reoccurred despite treatment. Pegcetacoplan, the first proximal complement C3 inhibitor, offers broad hemolysis control in pati …
Breakthrough hemolysis (BTH) was first described in patients with PNH treated with terminal complement C5 inhibitors when intravascular hemo …
Identification of amentoflavone as a potent SARS-CoV-2 Mpro inhibitor: a combination of computational studies and in vitro biological evaluation.
Bhattacharya P, Mandal A. Bhattacharya P, et al. J Biomol Struct Dyn. 2024 Jan 23:1-19. doi: 10.1080/07391102.2024.2304676. Online ahead of print. J Biomol Struct Dyn. 2024. PMID: 38263736
End-state effective free energy calculations using MM-PBSA calculations further suggested that (R(a))-amentoflavone (C3'-C8''-atropisomer) may show a greater binding affinity towards the M(pro) than (S(a))-amentoflavone. ...
End-state effective free energy calculations using MM-PBSA calculations further suggested that (R(a))-amentoflavone (C3'-C8''-atropis …
660 results