Clapp DW - Search Results

1

Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.

Chang LS, Oblinger JL, Smith AE, Ferrer M, Angus SP, Hawley E, Petrilli AM, Beauchamp RL, Riecken LB, Erdin S, Poi M, Huang J, Bessler WK, Zhang X, Guha R, Thomas C, Burns SS, Gilbert TSK, Jiang L, Li X, Lu Q, Yuan J, He Y, Dixon SAH, Masters A, Jones DR, Yates CW, Haggarty SJ, La Rosa S, Welling DB, Stemmer-Rachamimov AO, Plotkin SR, Gusella JF, Guinney J, Morrison H, Ramesh V, Fernandez-Valle C, Johnson GL, Blakeley JO, Clapp DW; Synodos for NF2 Consortium. Chang LS, et al. Among authors: clapp dw. PLoS One. 2021 Jul 15;16(7):e0252048. doi: 10.1371/journal.pone.0252048. eCollection 2021. PLoS One. 2021. PMID: 34264955 Free PMC article.

2

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling.

Yang FC, Chen S, Clegg T, Li X, Morgan T, Estwick SA, Yuan J, Khalaf W, Burgin S, Travers J, Parada LF, Ingram DA, Clapp DW. Yang FC, et al. Among authors: clapp dw. Hum Mol Genet. 2006 Aug 15;15(16):2421-37. doi: 10.1093/hmg/ddl165. Epub 2006 Jul 11. Hum Mol Genet. 2006. PMID: 16835260 Free PMC article.

3

K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells.

Khalaf WF, Yang FC, Chen S, White H, Bessler W, Ingram DA, Clapp DW. Khalaf WF, et al. Among authors: clapp dw. J Immunol. 2007 Feb 15;178(4):2527-34. doi: 10.4049/jimmunol.178.4.2527. J Immunol. 2007. PMID: 17277161

4

Nf1+/- mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway.

Lasater EA, Bessler WK, Mead LE, Horn WE, Clapp DW, Conway SJ, Ingram DA, Li F. Lasater EA, et al. Among authors: clapp dw. Hum Mol Genet. 2008 Aug 1;17(15):2336-44. doi: 10.1093/hmg/ddn134. Epub 2008 Apr 28. Hum Mol Genet. 2008. PMID: 18442999 Free PMC article.

5

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.

McDaniel AS, Allen JD, Park SJ, Jaffer ZM, Michels EG, Burgin SJ, Chen S, Bessler WK, Hofmann C, Ingram DA, Chernoff J, Clapp DW. McDaniel AS, et al. Among authors: clapp dw. Blood. 2008 Dec 1;112(12):4646-54. doi: 10.1182/blood-2008-04-155085. Epub 2008 Sep 2. Blood. 2008. PMID: 18768391 Free PMC article.

6

Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow.

Yang FC, Ingram DA, Chen S, Zhu Y, Yuan J, Li X, Yang X, Knowles S, Horn W, Li Y, Zhang S, Yang Y, Vakili ST, Yu M, Burns D, Robertson K, Hutchins G, Parada LF, Clapp DW. Yang FC, et al. Among authors: clapp dw. Cell. 2008 Oct 31;135(3):437-48. doi: 10.1016/j.cell.2008.08.041. Cell. 2008. PMID: 18984156 Free PMC article.

7

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

Allen JD, Jaffer ZM, Park SJ, Burgin S, Hofmann C, Sells MA, Chen S, Derr-Yellin E, Michels EG, McDaniel A, Bessler WK, Ingram DA, Atkinson SJ, Travers JB, Chernoff J, Clapp DW. Allen JD, et al. Among authors: clapp dw. Blood. 2009 Mar 19;113(12):2695-705. doi: 10.1182/blood-2008-06-160861. Epub 2009 Jan 5. Blood. 2009. PMID: 19124833 Free PMC article.

8

Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.

Chen S, Burgin S, McDaniel A, Li X, Yuan J, Chen M, Khalaf W, Clapp DW, Yang FC. Chen S, et al. Among authors: clapp dw. Am J Pathol. 2010 Dec;177(6):3125-32. doi: 10.2353/ajpath.2010.100369. Epub 2010 Oct 29. Am J Pathol. 2010. PMID: 21037083 Free PMC article.

9

Kinase suppressor of Ras (KSR1) modulates multiple kit-ligand-dependent mast cell functions.

Chen M, Burgin S, Staser K, He Y, Li X, Robinson M, Jiang L, Chan RJ, Ingram D, Clapp DW. Chen M, et al. Among authors: clapp dw. Exp Hematol. 2011 Oct;39(10):969-76. doi: 10.1016/j.exphem.2011.06.009. Epub 2011 Jul 1. Exp Hematol. 2011. PMID: 21726514 Free PMC article.

10

The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1.

Wu X, Chen S, He Y, Rhodes SD, Mohammad KS, Li X, Yang X, Jiang L, Nalepa G, Snider P, Robling AG, Clapp DW, Conway SJ, Guise TA, Yang FC. Wu X, et al. Among authors: clapp dw. PLoS One. 2011;6(9):e24917. doi: 10.1371/journal.pone.0024917. Epub 2011 Sep 29. PLoS One. 2011. PMID: 21980365 Free PMC article.

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