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Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease.
Gasparotto J, Senger MR, Telles de Sá Moreira E, Brum PO, Carazza Kessler FG, Peixoto DO, Panzenhagen AC, Ong LK, Campos Soares M, Reis PA, Schirato GV, Góes Valente WC, Araújo Montoya BO, Silva FP, Fonseca Moreira JC, Dal-Pizzol F, Castro-Faria-Neto HC, Gelain DP. Gasparotto J, et al. Among authors: peixoto do. J Biol Chem. 2021 Aug;297(2):100979. doi: 10.1016/j.jbc.2021.100979. Epub 2021 Jul 22. J Biol Chem. 2021. PMID: 34303703 Free PMC article.
Nuclear RXRα and RXRβ receptors exert distinct and opposite effects on RA-mediated neuroblastoma differentiation.
Girardi CS, Rostirolla DC, Lini FJM, Brum PO, Delgado J, Ribeiro CT, Teixeira AA, Peixoto DO, Heimfarth L, Kunzler A, Moreira JCF, Gelain DP. Girardi CS, et al. Among authors: peixoto do. Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):317-328. doi: 10.1016/j.bbamcr.2018.11.014. Epub 2018 Dec 7. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30529222 Free article.
Oral administration of carvacrol/β-cyclodextrin complex protects against 6-hydroxydopamine-induced dopaminergic denervation.
Tiefensee Ribeiro C, Gasparotto J, Petiz LL, Brum PO, Peixoto DO, Kunzler A, da Rosa Silva HT, Bortolin RC, Almeida RF, Quintans-Junior LJ, Araújo AA, Moreira JCF, Gelain DP. Tiefensee Ribeiro C, et al. Among authors: peixoto do. Neurochem Int. 2019 Jun;126:27-35. doi: 10.1016/j.neuint.2019.02.021. Epub 2019 Mar 5. Neurochem Int. 2019. PMID: 30849398 Free article.
Intranasal HSP70 administration protects against dopaminergic denervation and modulates neuroinflammatory response in the 6-OHDA rat model.
Tiefensee Ribeiro C, Peixoto DO, Santos L, Saibro-Girardi C, Brum PO, Carazza-Kessler FG, Somensi N, Behrens LMP, Bittencourt RR, Soares LS, Silveira AK, de Oliveira J, Moreira JCF, Gasparotto J, Gelain DP. Tiefensee Ribeiro C, et al. Among authors: peixoto do. Brain Behav Immun Health. 2021 Mar 31;14:100253. doi: 10.1016/j.bbih.2021.100253. eCollection 2021 Jul. Brain Behav Immun Health. 2021. PMID: 34589762 Free PMC article.
Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).
Peixoto DO, Bittencourt RR, Gasparotto J, Kessler FGC, Brum PO, Somensi N, Girardi CS, Dos Santos da Silva L, Outeiro TF, Moreira JCF, Gelain DP. Peixoto DO, et al. J Neurochem. 2023 Sep 3. doi: 10.1111/jnc.15956. Online ahead of print. J Neurochem. 2023. PMID: 37661637
Transgenerational inheritance of methylmercury and vitamin A-induced toxicological effects in a Wistar rats environmental-based model.
Carazza-Kessler FG, Campos MS, Bittencourt RR, Rosa-Silva HTD, Brum PO, Silveira AK, Teixeira AA, Ribeiro CT, Peixoto DO, Santos L, Andrade G, Panzenhagen AC, Scheibel IM, Gelain DP, Fonseca Moreira JC. Carazza-Kessler FG, et al. Among authors: peixoto do. Chemosphere. 2024 Mar;351:141239. doi: 10.1016/j.chemosphere.2024.141239. Epub 2024 Jan 23. Chemosphere. 2024. PMID: 38272134