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Concentration-QT modelling shows no evidence of clinically significant QT interval prolongation with capivasertib at expected therapeutic concentrations.
Br J Clin Pharmacol. 2022 Feb;88(2):858-864. doi: 10.1111/bcp.15006. Epub 2021 Sep 28.
Br J Clin Pharmacol. 2022.
PMID: 34309049
Free PMC article.
Clinical Trial.
A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors.
Choudhury AD, Higano CS, de Bono JS, Cook N, Rathkopf DE, Wisinski KB, Martin-Liberal J, Linch M, Heath EI, Baird RD, García-Carbacho J, Quintela-Fandino M, Barry ST, de Bruin EC, Colebrook S, Hawkins G, Klinowska T, Maroj B, Moorthy G, Mortimer PG, Moschetta M, Nikolaou M, Sainsbury L, Shapiro GI, Siu LL, Hansen AR.
Choudhury AD, et al. Among authors: maroj b.
Clin Cancer Res. 2022 Jun 1;28(11):2257-2269. doi: 10.1158/1078-0432.CCR-21-3087.
Clin Cancer Res. 2022.
PMID: 35247924
Free PMC article.
Clinical Trial.
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A Science-Based Methodology Framework for the Assessment of Combination Safety Risks in Clinical Trials.
Patera AC, Maidment J, Maroj B, Mohamed A, Twomey K.
Patera AC, et al. Among authors: maroj b.
Pharmaceut Med. 2023 May;37(3):183-202. doi: 10.1007/s40290-023-00465-z. Epub 2023 Apr 26.
Pharmaceut Med. 2023.
PMID: 37099245
Free PMC article.
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