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Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway.
Ziosi M, Di Meo I, Kleiner G, Gao XH, Barca E, Sanchez-Quintero MJ, Tadesse S, Jiang H, Qiao C, Rodenburg RJ, Scalais E, Schuelke M, Willard B, Hatzoglou M, Tiranti V, Quinzii CM. Ziosi M, et al. Among authors: kleiner g. EMBO Mol Med. 2017 Jan;9(1):96-111. doi: 10.15252/emmm.201606356. EMBO Mol Med. 2017. PMID: 27856618 Free PMC article.
Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum.
Barca E, Kleiner G, Tang G, Ziosi M, Tadesse S, Masliah E, Louis ED, Faust P, Kang UJ, Torres J, Cortes EP, Vonsattel JP, Kuo SH, Quinzii CM. Barca E, et al. Among authors: kleiner g. J Neuropathol Exp Neurol. 2016 Jul;75(7):663-72. doi: 10.1093/jnen/nlw037. Epub 2016 May 27. J Neuropathol Exp Neurol. 2016. PMID: 27235405 Free PMC article.
Combined HDAC and Bromodomain Protein Inhibition Reprograms Tumor Cell Metabolism and Elicits Synthetic Lethality in Glioblastoma.
Zhang Y, Ishida CT, Ishida W, Lo SL, Zhao J, Shu C, Bianchetti E, Kleiner G, Sanchez-Quintero MJ, Quinzii CM, Westhoff MA, Karpel-Massler G, Canoll P, Siegelin MD. Zhang Y, et al. Among authors: kleiner g. Clin Cancer Res. 2018 Aug 15;24(16):3941-3954. doi: 10.1158/1078-0432.CCR-18-0260. Epub 2018 May 15. Clin Cancer Res. 2018. PMID: 29764852 Free PMC article.
Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma.
Ishida CT, Zhang Y, Bianchetti E, Shu C, Nguyen TTT, Kleiner G, Sanchez-Quintero MJ, Quinzii CM, Westhoff MA, Karpel-Massler G, Prabhu VV, Allen JE, Siegelin MD. Ishida CT, et al. Among authors: kleiner g. Clin Cancer Res. 2018 Nov 1;24(21):5392-5406. doi: 10.1158/1078-0432.CCR-18-1040. Epub 2018 Jul 23. Clin Cancer Res. 2018. PMID: 30037819 Free PMC article.
MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma.
Zhang Y, Nguyen TTT, Shang E, Mela A, Humala N, Mahajan A, Zhao J, Shu C, Torrini C, Sanchez-Quintero MJ, Kleiner G, Bianchetti E, Westhoff MA, Quinzii CM, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. Zhang Y, et al. Among authors: kleiner g. Cancer Res. 2020 Jan 1;80(1):30-43. doi: 10.1158/0008-5472.CAN-19-1389. Epub 2019 Nov 6. Cancer Res. 2020. PMID: 31694905 Free PMC article.
Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease.
Sidhom EH, Kim C, Kost-Alimova M, Ting MT, Keller K, Avila-Pacheco J, Watts AJ, Vernon KA, Marshall JL, Reyes-Bricio E, Racette M, Wieder N, Kleiner G, Grinkevich EJ, Chen F, Weins A, Clish CB, Shaw JL, Quinzii CM, Greka A. Sidhom EH, et al. Among authors: kleiner g. J Clin Invest. 2021 Mar 1;131(5):e141380. doi: 10.1172/JCI141380. J Clin Invest. 2021. PMID: 33444290 Free PMC article.
197 results