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New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug).
Nawaratne V, Leach K, Suratman N, Loiacono RE, Felder CC, Armbruster BN, Roth BL, Sexton PM, Christopoulos A. Nawaratne V, et al. Among authors: sexton pm. Mol Pharmacol. 2008 Oct;74(4):1119-31. doi: 10.1124/mol.108.049353. Epub 2008 Jul 15. Mol Pharmacol. 2008. PMID: 18628403
Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: implications for ligand screening and functional selectivity.
Stewart GD, Valant C, Dowell SJ, Mijaljica D, Devenish RJ, Scammells PJ, Sexton PM, Christopoulos A. Stewart GD, et al. Among authors: sexton pm. J Pharmacol Exp Ther. 2009 Oct;331(1):277-86. doi: 10.1124/jpet.109.158667. Epub 2009 Jul 29. J Pharmacol Exp Ther. 2009. PMID: 19641164 Free PMC article.
Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.
Koole C, Wootten D, Simms J, Valant C, Sridhar R, Woodman OL, Miller LJ, Summers RJ, Christopoulos A, Sexton PM. Koole C, et al. Among authors: sexton pm. Mol Pharmacol. 2010 Sep;78(3):456-65. doi: 10.1124/mol.110.065664. Epub 2010 Jun 14. Mol Pharmacol. 2010. PMID: 20547734 Free PMC article.
385 results