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Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca2+ Overload for the Treatment of Neurodegenerative Diseases and Stroke.
Viejo L, Rubio-Alarcón M, Arribas RL, Moreno-Castro M, Pérez-Marín R, Braun-Cornejo M, Estrada-Valencia M, de Los Ríos C. Viejo L, et al. Among authors: de los rios c. Molecules. 2021 Jul 24;26(15):4473. doi: 10.3390/molecules26154473. Molecules. 2021. PMID: 34361628 Free PMC article.
Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.
González-Lafuente L, Egea J, León R, Martínez-Sanz FJ, Monjas L, Perez C, Merino C, García-De Diego AM, Rodríguez-Franco MI, García AG, Villarroya M, López MG, de Los Ríos C. González-Lafuente L, et al. Among authors: de los rios c. ACS Chem Neurosci. 2012 Jul 18;3(7):519-29. doi: 10.1021/cn300009e. Epub 2012 Mar 26. ACS Chem Neurosci. 2012. PMID: 22860221 Free PMC article.
Gramine Derivatives Targeting Ca(2+) Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases.
Lajarín-Cuesta R, Nanclares C, Arranz-Tagarro JA, González-Lafuente L, Arribas RL, Araujo de Brito M, Gandía L, de Los Ríos C. Lajarín-Cuesta R, et al. Among authors: de los rios c. J Med Chem. 2016 Jul 14;59(13):6265-80. doi: 10.1021/acs.jmedchem.6b00478. Epub 2016 Jun 24. J Med Chem. 2016. PMID: 27280380 Free article.
84 results