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Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell. 2021 Aug 9;39(8):1163-1164. doi: 10.1016/j.ccell.2021.07.015.
Cancer Cell. 2021.
PMID: 34375611
Free article.
No abstract available.
Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Geuijen CAW, De Nardis C, Maussang D, Rovers E, Gallenne T, Hendriks LJA, Visser T, Nijhuis R, Logtenberg T, de Kruif J, Gros P, Throsby M.
Geuijen CAW, et al. Among authors: de nardis c.
Cancer Cell. 2018 May 14;33(5):922-936.e10. doi: 10.1016/j.ccell.2018.04.003.
Cancer Cell. 2018.
PMID: 29763625
Free article.
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A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.
De Nardis C, Hendriks LJA, Poirier E, Arvinte T, Gros P, Bakker ABH, de Kruif J.
De Nardis C, et al.
J Biol Chem. 2017 Sep 1;292(35):14706-14717. doi: 10.1074/jbc.M117.793497. Epub 2017 Jun 27.
J Biol Chem. 2017.
PMID: 28655766
Free PMC article.
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Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP).
De Nardis C, Lössl P, van den Biggelaar M, Madoori PK, Leloup N, Mertens K, Heck AJ, Gros P.
De Nardis C, et al.
J Biol Chem. 2017 Jan 20;292(3):912-924. doi: 10.1074/jbc.M116.758862. Epub 2016 Dec 12.
J Biol Chem. 2017.
PMID: 27956551
Free PMC article.
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Complement C1q Interacts With LRP1 Clusters II and IV Through a Site Close but Different From the Binding Site of Its C1r and C1s-Associated Proteases.
Fouët G, Gout E, Wicker-Planquart C, Bally I, De Nardis C, Dedieu S, Chouquet A, Gaboriaud C, Thielens NM, Kleman JP, Rossi V.
Fouët G, et al. Among authors: de nardis c.
Front Immunol. 2020 Oct 21;11:583754. doi: 10.3389/fimmu.2020.583754. eCollection 2020.
Front Immunol. 2020.
PMID: 33193398
Free PMC article.
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