Merkx R - Search Results

1

Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System*.

Janssen GV, Zhang S, Merkx R, Schiesswohl C, Chatterjee C, Darwin KH, Geurink PP, van der Heden van Noort GJ, Ovaa H. Janssen GV, et al. Among authors: merkx r. Chembiochem. 2021 Nov 3;22(21):3082-3089. doi: 10.1002/cbic.202100333. Epub 2021 Sep 12. Chembiochem. 2021. PMID: 34387015 Free PMC article.

2

Synthesis and evaluation of a selective fluorogenic Pup derived assay reagent for Dop, a potential drug target in Mycobacterium tuberculosis.

Merkx R, Burns KE, Slobbe P, El Oualid F, El Atmioui D, Darwin KH, Ovaa H. Merkx R, et al. Chembiochem. 2012 Sep 24;13(14):2056-60. doi: 10.1002/cbic.201200460. Epub 2012 Aug 24. Chembiochem. 2012. PMID: 22927162 Free PMC article.

3

An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis.

Jastrab JB, Wang T, Murphy JP, Bai L, Hu K, Merkx R, Huang J, Chatterjee C, Ovaa H, Gygi SP, Li H, Darwin KH. Jastrab JB, et al. Among authors: merkx r. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1763-72. doi: 10.1073/pnas.1423319112. Epub 2015 Mar 23. Proc Natl Acad Sci U S A. 2015. PMID: 25831519 Free PMC article.

4

Enhanced Delivery of Synthetic Labelled Ubiquitin into Live Cells by Using Next-Generation Ub-TAT Conjugates.

Hameed DS, Sapmaz A, Gjonaj L, Merkx R, Ovaa H. Hameed DS, et al. Among authors: merkx r. Chembiochem. 2018 Dec 18;19(24):2553-2557. doi: 10.1002/cbic.201800649. Epub 2018 Nov 27. Chembiochem. 2018. PMID: 30351505

5

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

Faesen AC, Luna-Vargas MP, Geurink PP, Clerici M, Merkx R, van Dijk WJ, Hameed DS, El Oualid F, Ovaa H, Sixma TK. Faesen AC, et al. Among authors: merkx r. Chem Biol. 2011 Dec 23;18(12):1550-61. doi: 10.1016/j.chembiol.2011.10.017. Chem Biol. 2011. PMID: 22195557

6

Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes.

de Jong A, Merkx R, Berlin I, Rodenko B, Wijdeven RH, El Atmioui D, Yalçin Z, Robson CN, Neefjes JJ, Ovaa H. de Jong A, et al. Among authors: merkx r. Chembiochem. 2012 Oct 15;13(15):2251-8. doi: 10.1002/cbic.201200497. Epub 2012 Sep 25. Chembiochem. 2012. PMID: 23011887 Free PMC article.

7

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H. Mulder MP, et al. Among authors: merkx r. Nat Chem Biol. 2016 Jul;12(7):523-30. doi: 10.1038/nchembio.2084. Epub 2016 May 16. Nat Chem Biol. 2016. PMID: 27182664 Free PMC article.

8

Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin.

El Oualid F, Merkx R, Ekkebus R, Hameed DS, Smit JJ, de Jong A, Hilkmann H, Sixma TK, Ovaa H. El Oualid F, et al. Among authors: merkx r. Angew Chem Int Ed Engl. 2010 Dec 27;49(52):10149-53. doi: 10.1002/anie.201005995. Angew Chem Int Ed Engl. 2010. PMID: 21117055 Free PMC article. No abstract available.

9

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.

Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA. Juenemann K, et al. Among authors: merkx r. Sci Rep. 2018 Jan 23;8(1):1405. doi: 10.1038/s41598-018-19538-0. Sci Rep. 2018. PMID: 29362455 Free PMC article.

10

Total Chemical Synthesis of SUMO and SUMO-Based Probes for Profiling the Activity of SUMO-Specific Proteases.

Mulder MPC, Merkx R, Witting KF, Hameed DS, El Atmioui D, Lelieveld L, Liebelt F, Neefjes J, Berlin I, Vertegaal ACO, Ovaa H. Mulder MPC, et al. Among authors: merkx r. Angew Chem Int Ed Engl. 2018 Jul 16;57(29):8958-8962. doi: 10.1002/anie.201803483. Epub 2018 Jun 14. Angew Chem Int Ed Engl. 2018. PMID: 29771001 Free PMC article.

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