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Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide.
Christie MP, Whitten AE, King GJ, Hu SH, Jarrott RJ, Chen KE, Duff AP, Callow P, Collins BM, James DE, Martin JL. Christie MP, et al. Among authors: chen ke. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9816-21. doi: 10.1073/pnas.1116975109. Epub 2012 Jun 5. Proc Natl Acad Sci U S A. 2012. PMID: 22670057 Free PMC article.
Neuropilin-1 is a host factor for SARS-CoV-2 infection.
Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, Shoemark DK, Simón-Gracia L, Bauer M, Hollandi R, Greber UF, Horvath P, Sessions RB, Helenius A, Hiscox JA, Teesalu T, Matthews DA, Davidson AD, Collins BM, Cullen PJ, Yamauchi Y. Daly JL, et al. Among authors: chen ke. Science. 2020 Nov 13;370(6518):861-865. doi: 10.1126/science.abd3072. Epub 2020 Oct 20. Science. 2020. PMID: 33082294 Free PMC article.
Community-Wide Experimental Evaluation of the PROSS Stability-Design Method.
Peleg Y, Vincentelli R, Collins BM, Chen KE, Livingstone EK, Weeratunga S, Leneva N, Guo Q, Remans K, Perez K, Bjerga GEK, Larsen Ø, Vaněk O, Skořepa O, Jacquemin S, Poterszman A, Kjær S, Christodoulou E, Albeck S, Dym O, Ainbinder E, Unger T, Schuetz A, Matthes S, Bader M, de Marco A, Storici P, Semrau MS, Stolt-Bergner P, Aigner C, Suppmann S, Goldenzweig A, Fleishman SJ. Peleg Y, et al. Among authors: chen ke. J Mol Biol. 2021 Jun 25;433(13):166964. doi: 10.1016/j.jmb.2021.166964. Epub 2021 Mar 27. J Mol Biol. 2021. PMID: 33781758 Free PMC article.
De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.
Chen KE, Guo Q, Hill TA, Cui Y, Kendall AK, Yang Z, Hall RJ, Healy MD, Sacharz J, Norwood SJ, Fonseka S, Xie B, Reid RC, Leneva N, Parton RG, Ghai R, Stroud DA, Fairlie DP, Suga H, Jackson LP, Teasdale RD, Passioura T, Collins BM. Chen KE, et al. Sci Adv. 2021 Dec 3;7(49):eabg4007. doi: 10.1126/sciadv.abg4007. Epub 2021 Dec 1. Sci Adv. 2021. PMID: 34851660 Free PMC article.
Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system.
Wu Y, Cui Z, Huang YH, de Veer SJ, Aralov AV, Guo Z, Moradi SV, Hinton AO, Deuis JR, Guo S, Chen KE, Collins BM, Vetter I, Herzig V, Jones A, Cooper MA, King GF, Craik DJ, Alexandrov K, Mureev S. Wu Y, et al. Among authors: chen ke. Nat Commun. 2022 Jan 11;13(1):260. doi: 10.1038/s41467-021-27854-9. Nat Commun. 2022. PMID: 35017494 Free PMC article.
1,776 results