McKerrow J - Search Results

1

Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors.

Barbosa da Silva E, Rocha DA, Fortes IS, Yang W, Monti L, Siqueira-Neto JL, Caffrey CR, McKerrow J, Andrade SF, Ferreira RS. Barbosa da Silva E, et al. Among authors: mckerrow j. J Med Chem. 2021 Sep 9;64(17):13054-13071. doi: 10.1021/acs.jmedchem.1c01151. Epub 2021 Aug 30. J Med Chem. 2021. PMID: 34461718

2

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.

Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. Du X, et al. J Med Chem. 2002 Jun 20;45(13):2695-707. doi: 10.1021/jm010459j. J Med Chem. 2002. PMID: 12061873

3

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Greenbaum DC, et al. Among authors: mckerrow jh. J Med Chem. 2004 Jun 3;47(12):3212-9. doi: 10.1021/jm030549j. J Med Chem. 2004. PMID: 15163200

4

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Mallari JP, et al. J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173229

Recent studies have shown that a cathepsin B like protease, TbcatB, is essential to the survival of T. brucei in vitro (Mackey, Z. B.; O'Brien, T. C.; Greenbaum, D. C.; Blank, R. B.; McKerrow, J. H. J. Biol. Chem. 2004, 279, 48426-48433). Herein, we describe …

Recent studies have shown that a cathepsin B like protease, TbcatB, is essential to the survival of T. brucei in vitro (Mackey, Z. B.; O'Bri …

5

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.

Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Mallari JP, et al. Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. doi: 10.1016/j.bmcl.2008.03.083. Epub 2008 Apr 8. Bioorg Med Chem Lett. 2008. PMID: 18420405 Free PMC article.

6

Divergent modes of enzyme inhibition in a homologous structure-activity series.

Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR. Ferreira RS, et al. J Med Chem. 2009 Aug 27;52(16):5005-8. doi: 10.1021/jm9009229. J Med Chem. 2009. PMID: 19637873 Free PMC article.

7

Structure-guided development of selective TbcatB inhibitors.

Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Mallari JP, et al. J Med Chem. 2009 Oct 22;52(20):6489-93. doi: 10.1021/jm900908p. J Med Chem. 2009. PMID: 19769357 Free PMC article.

8

Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors.

Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK. Ferreira RS, et al. Among authors: mckerrow jh. J Med Chem. 2010 Jul 8;53(13):4891-905. doi: 10.1021/jm100488w. J Med Chem. 2010. PMID: 20540517 Free PMC article.

9

4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency.

Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. Calvet CM, et al. Among authors: mckerrow jh. J Med Chem. 2014 Aug 28;57(16):6989-7005. doi: 10.1021/jm500448u. Epub 2014 Aug 19. J Med Chem. 2014. PMID: 25101801 Free PMC article.

10

Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.

Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. Vieira DF, et al. Among authors: mckerrow jh. J Med Chem. 2014 Dec 11;57(23):10162-75. doi: 10.1021/jm501568b. Epub 2014 Nov 25. J Med Chem. 2014. PMID: 25393646 Free PMC article.

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