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Rolapitant Is a Reversible Inhibitor of CYP2D6.
Glass SM, Leddy SM, Orwin MC, Miller GP, Furge KA, Furge LL. Glass SM, et al. Drug Metab Dispos. 2019 Jun;47(6):567-573. doi: 10.1124/dmd.118.085928. Epub 2019 Apr 5. Drug Metab Dispos. 2019. PMID: 30952677 Free PMC article.
CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712.
Glass SM, Martell CM, Oswalt AK, Osorio-Vasquez V, Cho C, Hicks MJ, Mills JM, Fujiwara R, Glista MJ, Kamath SS, Furge LL. Glass SM, et al. Drug Metab Dispos. 2018 Aug;46(8):1106-1117. doi: 10.1124/dmd.117.079871. Epub 2018 May 21. Drug Metab Dispos. 2018. PMID: 29784728 Free PMC article.
28 results