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A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.
Nat Commun. 2021 Sep 17;12(1):5525. doi: 10.1038/s41467-021-25468-9.
Nat Commun. 2021.
PMID: 34535664
Free PMC article.
In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment.
Hirschfield H, Bian CB, Higashi T, Nakagawa S, Zeleke TZ, Nair VD, Fuchs BC, Hoshida Y.
Hirschfield H, et al.
Exp Mol Med. 2018 Jan 5;50(1):e419. doi: 10.1038/emm.2017.164.
Exp Mol Med. 2018.
PMID: 29303513
Free PMC article.
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Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma.
Sojoodi M, Wei L, Erstad DJ, Yamada S, Fujii T, Hirschfield H, Kim RS, Lauwers GY, Lanuti M, Hoshida Y, Tanabe KK, Fuchs BC.
Sojoodi M, et al. Among authors: hirschfield h.
Cancer Prev Res (Phila). 2020 Jun;13(6):497-508. doi: 10.1158/1940-6207.CAPR-19-0383. Epub 2020 Apr 6.
Cancer Prev Res (Phila). 2020.
PMID: 32253266
Free PMC article.
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Cell type-specific pharmacological kinase inhibition for cancer chemoprevention.
Deshmukh M, Nakagawa S, Higashi T, Vincek A, Venkatesh A, Ruiz de Galarreta M, Koh AP, Goossens N, Hirschfield H, Bian CB, Fujiwara N, Ono A, Hoshida H, El-Abtah M, Ahmad NB, Lujambio A, Sanchez R, Fuchs BC, Poelstra K, Prakash J, Hoshida Y; Precision Liver Cancer Prevention Consortium.
Deshmukh M, et al. Among authors: hirschfield h.
Nanomedicine. 2018 Feb;14(2):317-325. doi: 10.1016/j.nano.2017.11.004. Epub 2017 Nov 20.
Nanomedicine. 2018.
PMID: 29157977
Free PMC article.
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Shared and Tissue-Specific Expression Signatures between Bone Marrow from Primary Myelofibrosis and Essential Thrombocythemia.
Ishikawa G, Fujiwara N, Hirschfield H, Varricchio L, Hoshida Y, Barosi G, Rosti V, Padilla M, Mazzarini M, Friedman SL, Hoffman R, Migliaccio AR.
Ishikawa G, et al. Among authors: hirschfield h.
Exp Hematol. 2019 Nov;79:16-25.e3. doi: 10.1016/j.exphem.2019.10.001. Epub 2019 Nov 1.
Exp Hematol. 2019.
PMID: 31678370
Free PMC article.
Clinical Trial.
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Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import.
Rodriguez-Bravo V, Pippa R, Song WM, Carceles-Cordon M, Dominguez-Andres A, Fujiwara N, Woo J, Koh AP, Ertel A, Lokareddy RK, Cuesta-Dominguez A, Kim RS, Rodriguez-Fernandez I, Li P, Gordon R, Hirschfield H, Prats JM, Reddy EP, Fatatis A, Petrylak DP, Gomella L, Kelly WK, Lowe SW, Knudsen KE, Galsky MD, Cingolani G, Lujambio A, Hoshida Y, Domingo-Domenech J.
Rodriguez-Bravo V, et al. Among authors: hirschfield h.
Cell. 2018 Aug 23;174(5):1200-1215.e20. doi: 10.1016/j.cell.2018.07.015. Epub 2018 Aug 9.
Cell. 2018.
PMID: 30100187
Free PMC article.
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Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results.
Taouli B, Hoshida Y, Kakite S, Chen X, Tan PS, Sun X, Kihira S, Kojima K, Toffanin S, Fiel MI, Hirschfield H, Wagner M, Llovet JM.
Taouli B, et al. Among authors: hirschfield h.
Eur Radiol. 2017 Nov;27(11):4472-4481. doi: 10.1007/s00330-017-4844-6. Epub 2017 Apr 24.
Eur Radiol. 2017.
PMID: 28439654
Free PMC article.
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CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Fujiwara N, Nakagawa H, Enooku K, Kudo Y, Hayata Y, Nakatsuka T, Tanaka Y, Tateishi R, Hikiba Y, Misumi K, Tanaka M, Hayashi A, Shibahara J, Fukayama M, Arita J, Hasegawa K, Hirschfield H, Hoshida Y, Hirata Y, Otsuka M, Tateishi K, Koike K.
Fujiwara N, et al. Among authors: hirschfield h.
Gut. 2018 Aug;67(8):1493-1504. doi: 10.1136/gutjnl-2017-315193. Epub 2018 Feb 6.
Gut. 2018.
PMID: 29437870
Free PMC article.
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