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Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function.
Eur J Neurosci. 2021 Nov;54(9):6987-7005. doi: 10.1111/ejn.15466. Epub 2021 Oct 7.
Eur J Neurosci. 2021.
PMID: 34536321
Free article.
Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggests neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease.
Vazquez-Villaseñor I, Garwood CJ, Heath PR, Simpson JE, Ince PG, Wharton SB.
Vazquez-Villaseñor I, et al.
Neuropathol Appl Neurobiol. 2020 Feb;46(2):171-185. doi: 10.1111/nan.12559. Epub 2019 Jun 17.
Neuropathol Appl Neurobiol. 2020.
PMID: 31077599
Free PMC article.
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Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons.
Ratcliffe LE, Vázquez Villaseñor I, Jennings L, Heath PR, Mortiboys H, Schwartzentruber A, Karyka E, Simpson JE, Ince PG, Garwood CJ, Wharton SB.
Ratcliffe LE, et al. Among authors: vazquez villasenor i.
Neuroscience. 2018 Oct 15;390:46-59. doi: 10.1016/j.neuroscience.2018.07.029. Epub 2018 Jul 27.
Neuroscience. 2018.
PMID: 30056117
Free PMC article.
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RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer's Disease Patients Identifies a miRNA Signature That May Impact Blood-Brain Barrier Integrity.
Vázquez-Villaseñor I, Smith CI, Thang YJR, Heath PR, Wharton SB, Blackburn DJ, Ridger VC, Simpson JE.
Vázquez-Villaseñor I, et al.
Int J Mol Sci. 2022 May 25;23(11):5913. doi: 10.3390/ijms23115913.
Int J Mol Sci. 2022.
PMID: 35682592
Free PMC article.
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Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors.
Garwood CJ, Ratcliffe LE, Morgan SV, Simpson JE, Owens H, Vazquez-Villaseñor I, Heath PR, Romero IA, Ince PG, Wharton SB.
Garwood CJ, et al. Among authors: vazquez villasenor i.
Mol Brain. 2015 Aug 22;8:51. doi: 10.1186/s13041-015-0138-6.
Mol Brain. 2015.
PMID: 26297026
Free PMC article.
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A Parkinson's Disease-relevant Mitochondrial and Neuronal Morphology High-throughput Screening Assay in LUHMES Cells.
Leah T, Vazquez-Villaseñor I, Ferraiuolo L, Wharton SB, Mortiboys H.
Leah T, et al. Among authors: vazquez villasenor i.
Bio Protoc. 2021 Jan 5;11(1):e3881. doi: 10.21769/BioProtoc.3881. eCollection 2021 Jan 5.
Bio Protoc. 2021.
PMID: 33732769
Free PMC article.
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Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity.
Perez-Nievas BG, Johnson L, Beltran-Lobo P, Hughes MM, Gammallieri L, Tarsitano F, Myszczynska MA, Vazquez-Villasenor I, Jimenez-Sanchez M, Troakes C, Wharton SB, Ferraiuolo L, Noble W.
Perez-Nievas BG, et al. Among authors: vazquez villasenor i.
J Neuroinflammation. 2021 Dec 28;18(1):306. doi: 10.1186/s12974-021-02371-0.
J Neuroinflammation. 2021.
PMID: 34963475
Free PMC article.
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