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Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice.
Papazian I, Tsoukala E, Boutou A, Karamita M, Kambas K, Iliopoulou L, Fischer R, Kontermann RE, Denis MC, Kollias G, Lassmann H, Probert L. Papazian I, et al. Among authors: fischer r. J Neuroinflammation. 2021 Sep 26;18(1):222. doi: 10.1186/s12974-021-02200-4. J Neuroinflammation. 2021. PMID: 34565380 Free PMC article.
Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration.
Dong Y, Fischer R, Naudé PJ, Maier O, Nyakas C, Duffey M, Van der Zee EA, Dekens D, Douwenga W, Herrmann A, Guenzi E, Kontermann RE, Pfizenmaier K, Eisel UL. Dong Y, et al. Among authors: fischer r. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12304-12309. doi: 10.1073/pnas.1605195113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791020 Free PMC article.
Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury.
Gerald MJ, Bracchi-Ricard V, Ricard J, Fischer R, Nandakumar B, Blumenthal GH, Williams R, Kontermann RE, Pfizenmaier K, Moxon KA, Bethea JR. Gerald MJ, et al. Among authors: fischer r. CNS Neurosci Ther. 2019 Aug;25(8):884-893. doi: 10.1111/cns.13125. Epub 2019 Apr 2. CNS Neurosci Ther. 2019. PMID: 30941924 Free PMC article.
Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis.
Fischer R, Padutsch T, Bracchi-Ricard V, Murphy KL, Martinez GF, Delguercio N, Elmer N, Sendetski M, Diem R, Eisel ULM, Smeyne RJ, Kontermann RE, Pfizenmaier K, Bethea JR. Fischer R, et al. Brain Behav Immun. 2019 Oct;81:247-259. doi: 10.1016/j.bbi.2019.06.021. Epub 2019 Jun 17. Brain Behav Immun. 2019. PMID: 31220564 Free PMC article.
TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes.
Fischer R, Sendetski M, Del Rivero T, Martinez GF, Bracchi-Ricard V, Swanson KA, Pruzinsky EK, Delguercio N, Rosalino MJ, Padutsch T, Kontermann RE, Pfizenmaier K, Bethea JR. Fischer R, et al. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17045-17050. doi: 10.1073/pnas.1902091116. Epub 2019 Aug 7. Proc Natl Acad Sci U S A. 2019. PMID: 31391309 Free PMC article.
4,263 results