Phosphatidic acid generated by PLD2 promotes the plasma membrane recruitment of IQGAP1 and neointima formation.
Wang Z, Cai M, Tay LWR, Zhang F, Wu P, Huynh A, Cao X, Di Paolo G, Peng J, Milewicz DM, Du G.
Wang Z, et al. Among authors: cai m.
FASEB J. 2019 Jun;33(6):6713-6725. doi: 10.1096/fj.201800390RR. Epub 2019 Feb 27.
FASEB J. 2019.
PMID: 30811216
Free PMC article.
These data reveal that the PLD2-PA-IQGAP1 pathway plays an important role in VSMC migration and injury-induced vascular remodeling, and implicate PLD2 as a candidate target for therapeutic interventions.-Wang, Z., Cai, M., Tay, L. W. R., Zhang, F., Wu, P., Huynh, A. …
These data reveal that the PLD2-PA-IQGAP1 pathway plays an important role in VSMC migration and injury-induced vascular remodeling, and impl …