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R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.
Mendoza P, Martínez-Martín N, Bovolenta ER, Reyes-Garau D, Hernansanz-Agustín P, Delgado P, Diaz-Muñoz MD, Oeste CL, Fernández-Pisonero I, Castellano E, Martínez-Ruiz A, Alonso-Lopez D, Santos E, Bustelo XR, Kurosaki T, Alarcón B. Mendoza P, et al. Sci Signal. 2018 May 29;11(532):eaal1506. doi: 10.1126/scisignal.aal1506. Sci Signal. 2018. PMID: 29844052
Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.
Lorenzo-Martín LF, Citterio C, Menacho-Márquez M, Conde J, Larive RM, Rodríguez-Fdez S, García-Escudero R, Robles-Valero J, Cuadrado M, Fernández-Pisonero I, Dosil M, Sevilla MA, Montero MJ, Fernández-Salguero PM, Paramio JM, Bustelo XR. Lorenzo-Martín LF, et al. Among authors: fernandez pisonero i. Oncogene. 2019 Jan;38(2):209-227. doi: 10.1038/s41388-018-0433-7. Epub 2018 Aug 7. Oncogene. 2019. PMID: 30087437 Free PMC article.
An unexpected tumor suppressor role for VAV1a.
Bustelo XR, Lorenzo-Martín LF, Cuadrado M, Fernández-Pisonero I, Robles-Valero J. Bustelo XR, et al. Among authors: fernandez pisonero i. Mol Cell Oncol. 2018 Feb 23;5(3):e1432257. doi: 10.1080/23723556.2018.1432257. eCollection 2018. Mol Cell Oncol. 2018. PMID: 30250888 Free PMC article.
Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis.
Rodríguez-Fdez S, Lorenzo-Martín LF, Fernández-Pisonero I, Porteiro B, Veyrat-Durebex C, Beiroa D, Al-Massadi O, Abad A, Diéguez C, Coppari R, Nogueiras R, Bustelo XR. Rodríguez-Fdez S, et al. Among authors: fernandez pisonero i. Nat Commun. 2020 Nov 16;11(1):5808. doi: 10.1038/s41467-020-19489-z. Nat Commun. 2020. PMID: 33199701 Free PMC article.
Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
Hortal AM, Oeste CL, Cifuentes C, Alcoceba M, Fernández-Pisonero I, Clavaín L, Tercero R, Mendoza P, Domínguez V, García-Flores M, Pintado B, Abia D, García-Macías C, Navarro-Bailón A, Bustelo XR, González M, Alarcón B. Hortal AM, et al. Among authors: fernandez pisonero i. Mol Cancer. 2022 Feb 4;21(1):35. doi: 10.1186/s12943-022-01496-x. Mol Cancer. 2022. PMID: 35120522 Free PMC article.
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