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The glucagon receptor antagonist desHis1Pro4Glu9-glucagon(Lys12PAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia.
Lafferty R, Tanday N, Dubey V, Coulter-Parkhill A, Vishal K, Moffett C, O'Harte F, Flatt PR, Irwin N. Lafferty R, et al. Among authors: coulter parkhill a. Mol Cell Endocrinol. 2023 Jun 15;570:111932. doi: 10.1016/j.mce.2023.111932. Epub 2023 Apr 18. Mol Cell Endocrinol. 2023. PMID: 37080378 Free article.