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WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2.
Aragão LGHS, Oliveira JT, Temerozo JR, Mendes MA, Salerno JA, Pedrosa CSG, Puig-Pijuan T, Veríssimo CP, Ornelas IM, Torquato T, Vitória G, Sacramento CQ, Fintelman-Rodrigues N, da Silva Gomes Dias S, Cardoso Soares V, Souza LRQ, Karmirian K, Goto-Silva L, Biagi D, Cruvinel EM, Dariolli R, Furtado DR, Bozza PT, Borges HL, Souza TML, Guimarães MZP, Rehen SK. Aragão LGHS, et al. Among authors: bozza pt. PeerJ. 2021 Oct 8;9:e12262. doi: 10.7717/peerj.12262. eCollection 2021. PeerJ. 2021. PMID: 34707939 Free PMC article.
The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication.
Sacramento CQ, de Melo GR, de Freitas CS, Rocha N, Hoelz LV, Miranda M, Fintelman-Rodrigues N, Marttorelli A, Ferreira AC, Barbosa-Lima G, Abrantes JL, Vieira YR, Bastos MM, de Mello Volotão E, Nunes EP, Tschoeke DA, Leomil L, Loiola EC, Trindade P, Rehen SK, Bozza FA, Bozza PT, Boechat N, Thompson FL, de Filippis AM, Brüning K, Souza TM. Sacramento CQ, et al. Among authors: bozza pt, bozza fa. Sci Rep. 2017 Jan 18;7:40920. doi: 10.1038/srep40920. Sci Rep. 2017. PMID: 28098253 Free PMC article.
Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae.
Ferreira AC, Zaverucha-do-Valle C, Reis PA, Barbosa-Lima G, Vieira YR, Mattos M, Silva PP, Sacramento C, de Castro Faria Neto HC, Campanati L, Tanuri A, Brüning K, Bozza FA, Bozza PT, Souza TML. Ferreira AC, et al. Among authors: bozza pt, bozza fa. Sci Rep. 2017 Aug 25;7(1):9409. doi: 10.1038/s41598-017-09797-8. Sci Rep. 2017. PMID: 28842610 Free PMC article.
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication.
Ferreira AC, Reis PA, de Freitas CS, Sacramento CQ, Villas Bôas Hoelz L, Bastos MM, Mattos M, Rocha N, Gomes de Azevedo Quintanilha I, da Silva Gouveia Pedrosa C, Rocha Quintino Souza L, Correia Loiola E, Trindade P, Rangel Vieira Y, Barbosa-Lima G, de Castro Faria Neto HC, Boechat N, Rehen SK, Brüning K, Bozza FA, Bozza PT, Souza TML. Ferreira AC, et al. Among authors: bozza pt, bozza fa. Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01389-18. doi: 10.1128/AAC.01389-18. Print 2019 Feb. Antimicrob Agents Chemother. 2019. PMID: 30455237 Free PMC article.
Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo.
de Freitas CS, Higa LM, Sacramento CQ, Ferreira AC, Reis PA, Delvecchio R, Monteiro FL, Barbosa-Lima G, James Westgarth H, Vieira YR, Mattos M, Rocha N, Hoelz LVB, Leme RPP, Bastos MM, Rodrigues GOL, Lopes CEM, Queiroz-Junior CM, Lima CX, Costa VV, Teixeira MM, Bozza FA, Bozza PT, Boechat N, Tanuri A, Souza TML. de Freitas CS, et al. Among authors: bozza pt, bozza fa. PLoS Negl Trop Dis. 2019 Jan 30;13(1):e0007072. doi: 10.1371/journal.pntd.0007072. eCollection 2019 Jan. PLoS Negl Trop Dis. 2019. PMID: 30699122 Free PMC article.
Agathisflavone, a Biflavonoid from Anacardium occidentale L., Inhibits Influenza Virus Neuraminidase.
de Freitas CS, Rocha MEN, Sacramento CQ, Marttorelli A, Ferreira AC, Rocha N, de Oliveira AC, de Oliveira Gomes AM, Dos Santos PS, da Silva EO, da Costa JP, de Lima Moreira D, Bozza PT, Silva JL, Barroso SPC, Souza TML. de Freitas CS, et al. Among authors: bozza pt. Curr Top Med Chem. 2020;20(2):111-120. doi: 10.2174/1568026620666191219150738. Curr Top Med Chem. 2020. PMID: 31854280
Atazanavir, Alone or in Combination with Ritonavir, Inhibits SARS-CoV-2 Replication and Proinflammatory Cytokine Production.
Fintelman-Rodrigues N, Sacramento CQ, Ribeiro Lima C, Souza da Silva F, Ferreira AC, Mattos M, de Freitas CS, Cardoso Soares V, da Silva Gomes Dias S, Temerozo JR, Miranda MD, Matos AR, Bozza FA, Carels N, Alves CR, Siqueira MM, Bozza PT, Souza TML. Fintelman-Rodrigues N, et al. Among authors: bozza pt, bozza fa. Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00825-20. doi: 10.1128/AAC.00825-20. Print 2020 Sep 21. Antimicrob Agents Chemother. 2020. PMID: 32759267 Free PMC article.
Non-permissive SARS-CoV-2 infection in human neurospheres.
Pedrosa CDSG, Goto-Silva L, Temerozo JR, Souza LRQ, Vitória G, Ornelas IM, Karmirian K, Mendes MA, Gomes IC, Sacramento CQ, Fintelman-Rodrigues N, Soares VC, Dias SDSG, Salerno JA, Puig-Pijuan T, Oliveira JT, Aragão LGHS, Torquato TCQ, Veríssimo C, Biagi D, Cruvinel EM, Dariolli R, Furtado DR, Borges HL, Bozza PT, Rehen S, Souza TML, Guimarães MZP. Pedrosa CDSG, et al. Among authors: bozza pt. bioRxiv [Preprint]. 2021 Jun 17:2020.09.11.293951. doi: 10.1101/2020.09.11.293951. bioRxiv. 2021. PMID: 33052345 Free PMC article. Updated. Preprint.
Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators.
Dias SSG, Soares VC, Ferreira AC, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, Teixeira L, Nunes da Silva MA, Barreto E, Mattos M, de Freitas CS, Azevedo-Quintanilha IG, Manso PPA, Miranda MD, Siqueira MM, Hottz ED, Pão CRR, Bou-Habib DC, Barreto-Vieira DF, Bozza FA, Souza TML, Bozza PT. Dias SSG, et al. Among authors: bozza pt, bozza fa. PLoS Pathog. 2020 Dec 16;16(12):e1009127. doi: 10.1371/journal.ppat.1009127. eCollection 2020 Dec. PLoS Pathog. 2020. PMID: 33326472 Free PMC article.
321 results