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Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.
Cai S, Moutal A, Yu J, Chew LA, Isensee J, Chawla R, Gomez K, Luo S, Zhou Y, Chefdeville A, Madura C, Perez-Miller S, Bellampalli SS, Dorame A, Scott DD, François-Moutal L, Shan Z, Woodward T, Gokhale V, Hohmann AG, Vanderah TW, Patek M, Khanna M, Hucho T, Khanna R. Cai S, et al. Among authors: scott dd. Sci Transl Med. 2021 Nov 10;13(619):eabh1314. doi: 10.1126/scitranslmed.abh1314. Epub 2021 Nov 10. Sci Transl Med. 2021. PMID: 34757807
The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels.
Zhou Y, Cai S, Moutal A, Yu J, Gómez K, Madura CL, Shan Z, Pham NYN, Serafini MJ, Dorame A, Scott DD, François-Moutal L, Perez-Miller S, Patek M, Khanna M, Khanna R. Zhou Y, et al. Among authors: scott dd. ACS Chem Neurosci. 2019 Dec 18;10(12):4834-4846. doi: 10.1021/acschemneuro.9b00547. Epub 2019 Nov 21. ACS Chem Neurosci. 2019. PMID: 31697467
Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS).
François-Moutal L, Felemban R, Scott DD, Sayegh MR, Miranda VG, Perez-Miller S, Khanna R, Gokhale V, Zarnescu DC, Khanna M. François-Moutal L, et al. Among authors: scott dd. ACS Chem Biol. 2019 Sep 20;14(9):2006-2013. doi: 10.1021/acschembio.9b00481. Epub 2019 Aug 27. ACS Chem Biol. 2019. PMID: 31241884 Free PMC article.
Structural Insights Into TDP-43 and Effects of Post-translational Modifications.
François-Moutal L, Perez-Miller S, Scott DD, Miranda VG, Mollasalehi N, Khanna M. François-Moutal L, et al. Among authors: scott dd. Front Mol Neurosci. 2019 Dec 17;12:301. doi: 10.3389/fnmol.2019.00301. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31920533 Free PMC article. Review.
An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties.
Mollasalehi N, Francois-Moutal L, Scott DD, Tello JA, Williams H, Mahoney B, Carlson JM, Dong Y, Li X, Miranda VG, Gokhale V, Wang W, Barmada SJ, Khanna M. Mollasalehi N, et al. Among authors: scott dd. ACS Chem Biol. 2020 Nov 20;15(11):2854-2859. doi: 10.1021/acschembio.0c00494. Epub 2020 Oct 12. ACS Chem Biol. 2020. PMID: 33044808 Free PMC article.
A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).
François-Moutal L, Jahanbakhsh S, Nelson ADL, Ray D, Scott DD, Hennefarth MR, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, Chapman E, Morris QD, Van Keuren-Jensen K, Hughes TR, Khanna R, Koehler C, Jen J, Gokhale V, Khanna M. François-Moutal L, et al. Among authors: scott dd. ACS Chem Biol. 2018 Oct 19;13(10):3000-3010. doi: 10.1021/acschembio.8b00745. Epub 2018 Sep 6. ACS Chem Biol. 2018. PMID: 30141626 Free PMC article.
35 results