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Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes.
Dall M, Hassing AS, Niu L, Nielsen TS, Ingerslev LR, Sulek K, Trammell SAJ, Gillum MP, Barrès R, Larsen S, Poulsen SS, Mann M, Ørskov C, Treebak JT. Dall M, et al. Among authors: gillum mp. J Biol Chem. 2021 Dec;297(6):101388. doi: 10.1016/j.jbc.2021.101388. Epub 2021 Nov 8. J Biol Chem. 2021. PMID: 34762911 Free PMC article.
N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis.
Grevengoed TJ, Trammell SAJ, McKinney MK, Petersen N, Cardone RL, Svenningsen JS, Ogasawara D, Nexøe-Larsen CC, Knop FK, Schwartz TW, Kibbey RG, Cravatt BF, Gillum MP. Grevengoed TJ, et al. Among authors: gillum mp. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24770-24778. doi: 10.1073/pnas.1916288116. Epub 2019 Nov 18. Proc Natl Acad Sci U S A. 2019. PMID: 31740614 Free PMC article.
Fasting- and ghrelin-induced food intake is regulated by NAMPT in the hypothalamus.
de Guia RM, Hassing AS, Skov LJ, Ratner C, Plucińska K, Madsen S, Diep TA, Dela Cruz GV, Trammell SAJ, Sustarsic EG, Emanuelli B, Gillum MP, Gerhart-Hines Z, Holst B, Treebak JT. de Guia RM, et al. Among authors: gillum mp. Acta Physiol (Oxf). 2020 Apr;228(4):e13437. doi: 10.1111/apha.13437. Epub 2020 Jan 14. Acta Physiol (Oxf). 2020. PMID: 31900990
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis.
Winther-Sørensen M, Galsgaard KD, Santos A, Trammell SAJ, Sulek K, Kuhre RE, Pedersen J, Andersen DB, Hassing AS, Dall M, Treebak JT, Gillum MP, Torekov SS, Windeløv JA, Hunt JE, Kjeldsen SAS, Jepsen SL, Vasilopoulou CG, Knop FK, Ørskov C, Werge MP, Bisgaard HC, Eriksen PL, Vilstrup H, Gluud LL, Holst JJ, Wewer Albrechtsen NJ. Winther-Sørensen M, et al. Among authors: gillum mp. Mol Metab. 2020 Dec;42:101080. doi: 10.1016/j.molmet.2020.101080. Epub 2020 Sep 13. Mol Metab. 2020. PMID: 32937194 Free PMC article.
57 results