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The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice.
Bayarri-Olmos R, Johnsen LB, Idorn M, Reinert LS, Rosbjerg A, Vang S, Hansen CB, Helgstrand C, Bjelke JR, Bak-Thomsen T, Paludan SR, Garred P, Skjoedt MO. Bayarri-Olmos R, et al. Among authors: bjelke jr. Elife. 2021 Nov 25;10:e70002. doi: 10.7554/eLife.70002. Elife. 2021. PMID: 34821555 Free PMC article.
SARS-CoV-2 Antibody Responses Are Correlated to Disease Severity in COVID-19 Convalescent Individuals.
Hansen CB, Jarlhelt I, Pérez-Alós L, Hummelshøj Landsy L, Loftager M, Rosbjerg A, Helgstrand C, Bjelke JR, Egebjerg T, Jardine JG, Sværke Jørgensen C, Iversen K, Bayarri-Olmos R, Garred P, Skjoedt MO. Hansen CB, et al. Among authors: bjelke jr. J Immunol. 2021 Jan 1;206(1):109-117. doi: 10.4049/jimmunol.2000898. Epub 2020 Nov 18. J Immunol. 2021. PMID: 33208457
A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Østergaard H, Lund J, Greisen PJ, Kjellev S, Henriksen A, Lorenzen N, Johansson E, Røder G, Rasch MG, Johnsen LB, Egebjerg T, Lund S, Rahbek-Nielsen H, Gandhi PS, Lamberth K, Loftager M, Andersen LM, Bonde AC, Stavenuiter F, Madsen DE, Li X, Holm TL, Ley CD, Thygesen P, Zhu H, Zhou R, Thorn K, Yang Z, Hermit MB, Bjelke JR, Hansen BG, Hilden I. Østergaard H, et al. Among authors: bjelke jr. Blood. 2021 Oct 7;138(14):1258-1268. doi: 10.1182/blood.2020010331. Blood. 2021. PMID: 34077951 Free PMC article.
SARS-CoV-2 Neutralizing Antibody Responses towards Full-Length Spike Protein and the Receptor-Binding Domain.
Bayarri-Olmos R, Idorn M, Rosbjerg A, Pérez-Alós L, Hansen CB, Johnsen LB, Helgstrand C, Zosel F, Bjelke JR, Öberg FK, Søgaard M, Paludan SR, Bak-Thomsen T, Jardine JG, Skjoedt MO, Garred P. Bayarri-Olmos R, et al. Among authors: bjelke jr. J Immunol. 2021 Aug 1;207(3):878-887. doi: 10.4049/jimmunol.2100272. Epub 2021 Jul 23. J Immunol. 2021. PMID: 34301847
Nonspecificity fingerprints for clinical-stage antibodies in solution.
Herling TW, Invernizzi G, Ausserwöger H, Bjelke JR, Egebjerg T, Lund S, Lorenzen N, Knowles TPJ. Herling TW, et al. Among authors: bjelke jr. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2306700120. doi: 10.1073/pnas.2306700120. Epub 2023 Dec 18. Proc Natl Acad Sci U S A. 2023. PMID: 38109540 Free PMC article.
Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide.
Østergaard H, Bjelke JR, Hansen L, Petersen LC, Pedersen AA, Elm T, Møller F, Hermit MB, Holm PK, Krogh TN, Petersen JM, Ezban M, Sørensen BB, Andersen MD, Agersø H, Ahmadian H, Balling KW, Christiansen ML, Knobe K, Nichols TC, Bjørn SE, Tranholm M. Østergaard H, et al. Among authors: bjelke jr. Blood. 2011 Aug 25;118(8):2333-41. doi: 10.1182/blood-2011-02-336172. Epub 2011 Jun 23. Blood. 2011. PMID: 21700771 Free PMC article.
Hyperglycosylation prolongs the circulation of coagulation factor IX.
Bolt G, Bjelke JR, Hermit MB, Hansen L, Karpf DM, Kristensen C. Bolt G, et al. Among authors: bjelke jr. J Thromb Haemost. 2012 Nov;10(11):2397-8. doi: 10.1111/j.1538-7836.2012.04911.x. J Thromb Haemost. 2012. PMID: 22938555 Free article. No abstract available.
Design of Biopharmaceutical Formulations Accelerated by Machine Learning.
Narayanan H, Dingfelder F, Condado Morales I, Patel B, Heding KE, Bjelke JR, Egebjerg T, Butté A, Sokolov M, Lorenzen N, Arosio P. Narayanan H, et al. Among authors: bjelke jr. Mol Pharm. 2021 Oct 4;18(10):3843-3853. doi: 10.1021/acs.molpharmaceut.1c00469. Epub 2021 Sep 14. Mol Pharm. 2021. PMID: 34519511 Free article.
18 results